DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and rph3aa

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_005172658.1	Gene:	rph3aa / 101886567	ZFINID:	ZDB-GENE-090706-2	Length:	598	Species:	Danio rerio

Alignment Length:	669	Identity:	141/669 - (21%)
Similarity:	238/669 - (35%)	Gaps:	185/669 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KRIESWSRMAKERVG--AVRRVTLDRNSADEGTPSGSGASSTAGGNGVSVVHILPIGEGSTTPPP 76
            :|.::...|.:||:|  |.|..::.|::..:|...........|..|||.|..
Zfish    24 ERAKTMEAMEQERIGRLANRLDSMKRSACGDGYSRCLLCGQQFGLTGVSAVVC------------ 76

  Fly    77 QPMTPPPSASSVTSTTSGIGSVSAGSVSDSCDLPTDSEEVAIAKECQPIQPASQLHGMHGGMGLN 141
                  ........|..|:.||..            |..:.:.|.|                 ..
Zfish    77 ------AECKKNMCTKCGVQSVCR------------SGPIWLCKIC-----------------CE 106

  Fly   142 HHHMGTVSATGTDILRG-PAEVFHSPLHLHHQSRSFPPRLQRTPSISSQS--------------- 190
            |..|  :..:|....:| |.:|..:||.:.:|......|....||.:.||
Zfish   107 HKEM--LKQSGAWFFKGSPQQVLPAPLAISNQRELSTSRTSTNPSANQQSPITSQTKNAESVQVT 169

  Fly   191 ------SVDSAPSRH--------------SGHRGSSPQI------RTFGPDGRSSLPSEPGFPHH 229
                  |.::.|::.              .|...|:.|.      :||.|..:..:|.:...|..
Zfish   170 GREQQISAETMPAKREERSVISQRALEEDGGRHRSTVQSDAAMEGQTFSPVVKREVPVQSSRPPA 234

  Fly   230 LARSPSPMR--TISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKGVAGGRCL 292
            .:.|.:|::  |:|.......||..|   |.|.|:.:.
Zfish   235 SSFSTTPIQKDTMSRPEARAPPAMQA---DARLPAANS--------------------------- 269

  Fly   293 SPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYLTAPESSHAVGRLHLRVKYDYHLFDL 357
                :|...||.              .|......|...|  ..:.:..:|.|...:.|.....:|
Zfish   270 ----VPASRQPP--------------PPTTEDEEDANSY--DSDDATTLGMLEFSLLYTEEKNEL 314

  Fly   358 TVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVD-SRKRQTHIHRGESNPYFDQHFKF-PVSRDQLQ 420
            ..::|:|..|.|::..|..||||:|.|.|... |.|.:|...|...||.:::...: .::.:.:|
Zfish   315 HCNIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRTTLNPVWNETLVYHGITNEDMQ 379

  Fly   421 GKELILQVLDYDRYSHNDIIGEVRISVDGLDL------------------------SKSVEIWGD 461
            .|.|.|.|.|.|::.||:.|||.|:.:..|.|                        |:.:.::.:
Zfish   380 KKTLRLSVSDEDKFGHNEFIGETRVVLKKLKLNQKKTYNVCLERVIPVRRTAGGGASRGMALYEE 444

  Fly   462 LLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNGKRIKKKK 521
            .|:..: .|:|..:|.||.|..|..||.|.:::..:|..:     .:|:|||.|..:..:..|.|
Zfish   445 ELKDDE-AEERGRILVSLTYNSQQGRLIVGVVRCAHLAAMDSNGYSDPFVKICLKPDMGKKAKYK 508

  Fly   522 TSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEI----YVVGAGSEATEIGCCGLGPQESGTGCQ 582
            |.|.|.  ..||.:||.|::.::...|....:::    |.:|..::.  ||.|.||....|...:
Zfish   509 TQIKKK--TLNPEFNEEFSYEIKHGELAKKTLDVSVWDYDMGKSNDF--IGGCQLGITAKGECLK 569

  Fly   583 HWHDMINNARKPTAMWHYI 601
            ||::.:.|..|....||.:
Zfish   570 HWYECLKNKDKKIERWHVL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	38/147 (26%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	39/136 (29%)
rph3aa	XP_005172658.1	PHD_SF	53..131	CDD:304600	19/126 (15%)
		C2A_Rabphilin_Doc2	298..421	CDD:176000	37/122 (30%)
		C2B_Rabphilin_Doc2	456..588	CDD:176030	39/135 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000