DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and sytl4

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_031746962.1	Gene:	sytl4 / 100495134	XenbaseID:	XB-GENE-958567	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	524	Identity:	120/524 - (22%)
Similarity:	200/524 - (38%)	Gaps:	117/524 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 SPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSEPGFPHH 229
            ||...|..|.|        |.:..|.|...:..:.|        :.::..|.:.|.||
Frog   179 SPQQQHKSSGS--------PDLRDQKSDTESTEQMS--------LSSYKTDSKKSSPS------- 220

  Fly   230 LARSPSPMRTISL-DARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGS-SAGKGVAGG--- 289
            .:|..|..::.:| ||:.......|:...|..|..|:....|.:.|..:.|| |||......
Frog   221 TSRRNSLEKSATLQDAKRAQGPVGANVATLTVPVRSRDRHQSDSEGEALLGSRSAGSADESDTLF 285

  Fly   290 -----RCLSPLLIPPRSQPGVDPAMGPASP----LGALQP--------------------DLYRM 325
                 |.|.|   ...|:..:|....||:|    ||....                    :::|:
Frog   286 KKNPRRLLKP---ADYSKSVLDLRPEPAAPEENALGDRSKSVPRLNIEMEEEDEDIDNLVEIHRL 347

  Fly   326 PDGPVYLTAPESSHAV-------------------GRLHLRVKYDYHLFDLTVHLIEAHNLSPIE 371
            ..|...|.:..||..:                   |.:...:.||..:..|.:.:.|..||:..:
Frog   348 SAGRSSLRSGASSSTLGSMISIYSEAGDFGNVIITGEIIFSINYDAKVQLLNILVKECRNLAYGD 412

  Fly   372 EGGFR-DPYVRLMLQPEVDSR-KRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRY 434
            |...| :||::..|.|:...: ||:|.|.|..:||.:::..|:.|....|..:.|.|.|..|||:
Frog   413 ELKMRSNPYIKSYLLPDKSRQGKRKTTIKRNTTNPMYNEVLKYIVPESMLHLRSLELSVWHYDRF 477

  Fly   435 SHNDIIGEVRISVDGLDLSKSVEIW------GDLLRTKKPKEDRPELLCSLNYLPQ-----AER- 487
            ..|..:|:|.|.:|..:....:|..      |::.........:.||:.||.|:|.     :||
Frog   478 GRNTFLGQVDIPLDSWNFDSLIEECLPLHGKGNMDSGAGFYNSKGELVVSLKYVPPTKPSGSERR 542

  Fly   488 ---------LTVVIMKARNLDT-----LQEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEA 538
                     |.|.|.:|:||..     :.:.:||.||..:..:..|:||.:.|.  ..||.:|..
Frog   543 KKKADEGGELHVWIKEAKNLTAVKTGGISDSFVKGYLFPHKNKNTKRKTPVVKK--TLNPHYNHT 605

  Fly   539 FTFN-LQSNYLHNAAIEIYVVGAG--SEATEIGCCGLGPQESGTGCQHWH--DMINNARKPTAMW 598
            |.:| ::...|.|..:|:.|....  |....:|...||   .|.|..:..  |.:::..:..::|
Frog   606 FVYNGIKPEDLQNVCLELTVWDREPLSSNDFLGGVRLG---IGNGMSNGELVDWMDSTGEELSLW 667

  Fly   599 HYIR 602
            ..:|
Frog   668 QKMR 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	36/148 (24%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	39/152 (26%)
sytl4	XP_031746962.1	PHD_SF	15..126	CDD:419867
		FYVE_Slp4	63..112	CDD:277303
		C2A_SLP-4_5	382..506	CDD:175995	35/123 (28%)
		C2B_SLP_1-2-3-4	521..685	CDD:175987	40/156 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910