DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and rph3a

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_031748610.1	Gene:	rph3a / 100487950	XenbaseID:	XB-GENE-5881709	Length:	703	Species:	Xenopus tropicalis

Alignment Length:	487	Identity:	117/487 - (24%)
Similarity:	194/487 - (39%)	Gaps:	83/487 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 SFPPRLQRTPS--ISSQSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSEPGFPHHLARSPSPM 237
            ::||..::..|  ..|.|..:...:|.|.:.|....|.. .|.|.....|..|     .|..|.:
Frog   233 NYPPPARKAESRMAPSGSEYEGEETRDSSYGGVDNDINR-SPGGVKRGSSVQG-----TRPTSAV 291

  Fly   238 RTISLDARCGSPAHSADPGDLRTP---------------SPSQSSLASLAGGSGMGGSSAGKGVA 287
            :..::.....:|..||.|....||               |..:|:.::....:....|...:||.
Frog   292 QGSNIQPTQQAPPASARPAARPTPANRFPEEQGGTTLPASQPESTYSASVPRNEKADSFTPQGVR 356

  Fly   288 GGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYLTAPESSHAVGRLHLRVKYDY 352
            ..|.|........|.|.|      |:| .|.||......:........:.:..:|.|...:.||.
Frog   357 QDRPLRQAASYTSSVPTV------AAP-SARQPQTQDEEEEEANSYDSDEATTLGSLEFSLFYDQ 414

  Fly   353 HLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVD-SRKRQTHIHRGESNPYFDQHFKF-PVS 415
            ....|...:|:|..|.|::..|..||||:|.|.|... :.|.:|...|...||.:::...: .::
Frog   415 ENNSLHCGIIKAKGLKPMDSNGLADPYVKLHLLPGASKANKLRTKTLRNTRNPIWNETLVYHGIT 479

  Fly   416 RDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGL--DLSKSVEI-------------------- 458
            .::||.|.|.:.|.|.|::.||:.|||.|.|:..|  :..||..:
Frog   480 DEELQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQKKSFNVCLERVIPMKRAGTTGSVRGM 544

  Fly   459 ---------WGDLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIY 509
                     .||:       |:|.::|.||.|..|...|.|.|::..:|..:     .:|:||::
Frog   545 ALYEDENDRGGDV-------EERGKILVSLMYNTQQGGLIVGIVRCVHLAAMDANGYSDPFVKLW 602

  Fly   510 LIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEI----YVVGAGSEATEIGCC 570
            |..:..:..|.||.|.|.  ..||.:||.|.:.::.:.|....:::    |.:|..::  .||.|
Frog   603 LKPDMGKKAKNKTQIKKK--TLNPEFNEEFFYEIKHSDLAKKQLDVSVWDYDIGKSND--YIGGC 663

  Fly   571 GLGPQESGTGCQHWHDMINNARKPTAMWHYIR 602
            .||....|...:||::.:.|..|....||.::
Frog   664 QLGINAKGERLKHWYECLKNKDKKIERWHVLQ 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	41/154 (27%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	38/136 (28%)
rph3a	XP_031748610.1	FYVE_RP3A	92..171	CDD:277301
		C2A_Rabphilin_Doc2	403..526	CDD:176000	39/122 (32%)
		C2B_Rabphilin_Doc2	562..694	CDD:176030	38/135 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910