Protein Alignment Sytbeta and doc2b

DIOPT Version :10

• Sequence 1: NP_648734.1
• Gene: Sytbeta / 39630
• FlyBaseID: FBgn0261090
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: XP_017211854.1
• Gene: doc2b / 100006713
• ZFINID: ZDB-GENE-090615-1
• Length: 648
• Species: Danio rerio
• Alignment Length: 664
• Identity: 162/664 - (24%)
• Similarity: 247/664 - (37%)
• Gaps: 168/664 - (25%)

  Fly    15 RIESWSRMAKERVG-AVRRVTLDRNSADEGTPSGSGASSTAGGNGVSVVHILPIGE-----GSTT 73
            |.|....:.:.|:| .|.|:              ....|:|.|||:|  ..|..||     ||
Zfish    61 RAEQLELIEQHRIGRLVERL--------------DNMRSSAMGNGLS--QCLLCGEVFGLLGS-- 107

  Fly    74 PPPQPMTPPPSASSV--------TSTTSGIGSVSAGSVSDS--CDLPTDSEEV----------AI 118
                        |||        ..|..||.:.:.|.....  |.:.::..||          |:
Zfish   108 ------------SSVLCLDCCMKVCTKCGIETTAGGQKRTQWLCKICSEQREVWKRSGAWFYKAL 160

  Fly   119 AKECQPIQPA---SQLHGMHGGMGLNHHHMGTVSAT------------GTDI----LRGPAEVFH 164
            .|..:||:.:   ::...:..|..|.......:|.|            |:|.    .....:.|.
Zfish   161 PKHIRPIKDSILDNRKPVIERGEQLPVARSAPISYTWAQSRVYLSESDGSDAELSECSSDRKTFA 225

  Fly   165 SPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSE------ 223
            |..:....|.|...::| ||    |||..| |:|.:.|. .||          |||.||
Zfish   226 SETNQRRDSESSGGQVQ-TP----QSSFTS-PTRGNVHI-ESP----------SSLVSEQSSSSS 273

  Fly   224 --PGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKGV 286
              ||....:......:.|....:|.||         ||:.|.||.|....|..:
Zfish   274 FNPGLEDEVIDHSRTLLTPPALSRAGS---------LRSSSTSQKSEGPQADAN----------- 318

  Fly   287 AGGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYLTAPESSHAVGRLHLRVKYD 351
                         |.:..:|.|.| |:.|.|.:.:  ..||...|  ..:.|..:|.|...:.||
Zfish   319 -------------RDEDDLDQAFG-ATALVASKKE--EEPDVEGY--DSDDSTTLGTLDFSLLYD 365

  Fly   352 YHLFDLTVHLIEA--------HNLSPIEEGGFRDPYVRLMLQPEVD-SRKRQTHIHRGESNPYFD 407
            .....|...:.:|        ..|.|::..|..||||:|.|.|... :.|.:|...|...||.:.
Zfish   366 QENNALHCTINKAKLPVPRYKKGLKPMDHNGLSDPYVKLHLLPGASKANKLRTKTLRNTLNPVWS 430

  Fly   408 QHFK-FPVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGL------DLSKSVEIWGDLLRT 465
            :... :.::.:.:..|.|.:.|.|.|::.||:.|||.||.:..|      :.|..:|....:.:|
Zfish   431 ETLTYYGITDEDMVRKTLRISVCDEDKFRHNEFIGETRIPLKKLKPNQTKNFSNCLEKQLPIDKT 495

  Fly   466 -KKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNGKRIKKKKTSI 524
             .|..|:|..::.||.|..|...|.|.|::..:|..:     .:||||.||..:..:..|.||::
Zfish   496 DDKSLEERGRIMISLKYSSQKSGLVVGIIRCAHLAAMDANGFSDPYVKTYLKPDENKKSKHKTAV 560

  Fly   525 TKSDDPTNPIWNEAFTFNLQSNYLHNAAIEI----YVVGAGSEATEIGCCGLGPQESGTGCQHWH 585
            .|.  ..||.:||.|.:.::...|....:|:    |.:|..::.  ||...||...||...:||.
Zfish   561 KKK--TLNPEFNEEFFYEIKYADLSKKTLEVTVWDYDIGKSNDF--IGGVSLGINASGERLKHWF 621

  Fly   586 DMINNARKPTAMWH 599
            |.:.|..|....||
Zfish   622 DCLKNKDKKIERWH 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	PHA03307	39..>267	CDD:223039	63/279 (23%)
		C2	341..463	CDD:472691	36/137 (26%)
		C2B_Synaptotagmin	473..601	CDD:175975	40/136 (29%)
doc2b	XP_017211854.1	PHD_SF	51..158	CDD:473978	27/126 (21%)
		C2A_Rabphilin_Doc2	355..486	CDD:176000	35/130 (27%)
		C2B_Rabphilin_Doc2	505..637	CDD:176030	40/135 (30%)