DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reck and RECK

DIOPT Version :9

Sequence 1:	NP_001261853.1	Gene:	Reck / 39629	FlyBaseID:	FBgn0036463	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_066934.1	Gene:	RECK / 8434	HGNCID:	11345	Length:	971	Species:	Homo sapiens

Alignment Length:	1012	Identity:	333/1012 - (32%)
Similarity:	514/1012 - (50%)	Gaps:	132/1012 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 SPGESYDIFTCCNQVFGS--CRTACENLSLVEFATGTGGDNRDELHR---YCQLHQVEFWTCVNQ 163
            :||.:..:  |||....:  ||..||.:    |::.:....:..|.|   ||....||.|.|:|.
Human    29 APGSAGAL--CCNHSKDNQMCRDVCEQI----FSSKSESRLKHLLQRAPDYCPETMVEIWNCMNS 87

  Fly   164 TFDAITRGAD-WSGRRCCQFGVLPHCRNVC--ATSTRSPVQNCRRSDEQTLYDCLERQEAADQCC 225
            :...:.:.:| |.|..||:..:...||..|  |:|.....:.||:..|..|:.|:.|.|....||
Human    88 SLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCC 152

  Fly   226 GQA-RTSECLEACRAVFE----------PANDNHDHVDINGACGDRNADVIQCVNNHTDMTPLAN 279
            ..| ..:.|.|.|:|:|.          .|.:|:        |...:..:|.||||:|...|:.|
Human   153 SYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENY--------CASISPQLIHCVNNYTQSYPMRN 209

  Fly   280 AEQYIPCCEYSSKEHCRHTCRNLLHQNATLMERSEVIFGRLEAAGCGS-PLPQLPFWQCFLTVTG 343
            ....:.||:.:....|::.|:.:|....|.|   |::.|.:|  ||.: ||||.|.|||||..:.
Human   210 PTDSLYCCDRAEDHACQNACKRILMSKKTEM---EIVDGLIE--GCKTQPLPQDPLWQCFLESSQ 269

  Fly   344 KLYVPGGSGRAGGSLAQGRISGQGGSLAEPNHLGMDAAKRQCCEQASSHKCRRLCNQIFTSNWWD 408
            .::                   .|.::..|...|:|.||..||.:|::..||.||.::::.:|.:
Human   270 SVH-------------------PGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGN 315

  Fly   409 ARS--SFENECMDQPGERELRRCIESVDAPCELGCQGLSFCSNFNNRPTELFRSCTPEHDAAARE 471
            .:|  .|:..|...|.|..:..|:..|..||:|||:.|::|:|||||||||||||..:.|..|..
Human   316 TQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMN 380

  Fly   472 DWQLLQQRGTVRVLGQELFIKNTSRCAPDKWRALVCALQLKPCTRVGLFNGICSEDCHELLDECL 536
            |.: |.::|::::....:.:.:..:|.|:.|:|:.|:||:|||......:.||..||.|:|.:|.
Human   381 DMK-LWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCG 444

  Fly   537 DWTLQHQRPKD-----ICSRLKEKDDDDSPLPCISLESYLKP---GDASPEEFQGITSPCAQKPC 593
            |   |::.|:|     ||..|...||..:   ||.|::||:|   |:...|    :|.||...||
Human   445 D---QNKFPEDHTAESICELLSPTDDLKN---CIPLDTYLRPSTLGNIVEE----VTHPCNPNPC 499

  Fly   594 NGSEVCILQRGGNQG------YSCIPGCNLGQDSKLFVPFGSYVRLGKSNLHKKLEVGQFPLAEH 652
            ..:|:|.:.|.|...      |.|:.||.||:.|...|..|:.:::..|    ..|||.:.
Human   500 PANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSS----AGEVGCYK---- 556

  Fly   653 IVCSCGLQGRLEQCQPLPSYMHAHC------TLPGARSYRHGSSFYLECNLCSCFAGEITCTKQQ 711
             :||||..|.||.|      |..||      .:.|.:...||:||.::||:||||||.:.|:.:.
Human   557 -ICSCGQSGLLENC------MEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRL 614

  Fly   712 CRLPGFVDSG---YTSLPCNCPAHYVPVCGSNGNTYPSACVAKC-HLPEGDYVYGACNARNACQA 772
            |......:..   :|.|||||...:|||||.||.||||||:|:| .|.:..:.:|:|.:::.|.
Human   615 CLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCN- 678

  Fly   773 APPNSCPSGTQCLDSRKVCLASMQR-PCLQYVCVNATASNCSTFHQGEVCDSQGRTYPNACALLK 836
              ||.|....:|:...:|||.:..: .|.||.||....: |... |..|||:....:.|.|.|.:
Human   679 --PNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLA-CDQV-QDPVCDTDHMEHNNLCTLYQ 739

  Fly   837 ANPQGQVAYWSACQSSRFNTSPSPVCGINGVTYKSSYAARAEYVLVDYVGRCREVGLLVSDMG-R 900
            ...  .::|...||.  |..:..||||.||.||.|..||.::.|.|||.|.|:.||:|..... .
Human   740 RGK--SLSYKGPCQP--FCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVA 800

  Fly   901 RCRTVKCPAPVSKHCRLIVPPGACCPLCAGGAFRIIYSRKQFDRAMYGLRAQSSTLLTLQGVLQQ 965
            .|.:||||:.::..|:.|:|||||||||| |..|:::.:::.|..   .:..:...:|:..:||:
Human   801 ECASVKCPSLLAAGCKPIIPPGACCPLCA-GMLRVLFDKEKLDTI---AKVTNKKPITVLEILQK 861

  Fly   966 LDGLVQVSECQLTGFLTMEVGIFVAIVPSSSIKRPTHLQLEACAREAEKISSLINAQSPRITTNL 1030
            :...|.|.:|.:.|:.::|..|.:.|:|....  |..||:|||.:|||||.||||:.||.:.:::
Human   862 IRMHVSVPQCDVFGYFSIESEIVILIIPVDHY--PKALQIEACNKEAEKIESLINSDSPTLASHV 924

  Fly  1031 ALSCLTVS--HLLEPTPNGATSYGP--HAIWILPLLL 1063
            .||.|.:|  .:....|:......|  |:: :|||.|
Human   925 PLSALIISQVQVSSSVPSAGVRARPSCHSL-LLPLSL 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reck	NP_001261853.1	KAZAL_FS	729..>753	CDD:238052	16/24 (67%)
RECK	NP_066934.1	OATP	<633..>658	CDD:281175	17/24 (71%)
RECK	NP_066934.1	Amnionless	<802..>886	CDD:291494	29/87 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142932
Domainoid	1	1.000	339	1.000	Domainoid score	I1105
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9622
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1171
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49635
OrthoDB	1	1.010	-	-		D279140at33208
OrthoFinder	1	1.000	-	-		FOG0007351
OrthoInspector	1	1.000	-	-		oto91489
orthoMCL	1	0.900	-	-		OOG6_108997
Panther	1	1.100	-	-	LDO	PTHR13487
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5670
SonicParanoid	1	1.000	-	-		X5473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800