DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reck and Spink5

DIOPT Version :9

Sequence 1:	NP_001261853.1	Gene:	Reck / 39629	FlyBaseID:	FBgn0036463	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_001074649.1	Gene:	Spink5 / 72432	MGIID:	1919682	Length:	1017	Species:	Mus musculus

Alignment Length:	800	Identity:	143/800 - (17%)
Similarity:	239/800 - (29%)	Gaps:	316/800 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 CRNVCATSTRSPVQNCR------RSDEQTLYDC---LERQEAADQCCGQARTSEC-------LEA 236
            |:........:.:.|.:      |:.:....:|   .:|::..|..|....:|.|       ...
Mouse    66 CKRALEQGAPTKIMNVKVLSRANRATDPAKLNCESFKQRRKDGDFICPSDTSSVCGTDGKTYRSR 130

  Fly   237 CRAVFEPANDNHDHVDI--NGACGDRNADVIQCVNNHTDMTPLANAEQYIPCCEYSSKEHCRHTC 299
            |....|.|. :.:|||:  .|.||..:.:        |||           |.::
Mouse   131 CELCAENAK-SQNHVDVKSEGECGSSHLE--------TDM-----------CSDF---------- 165

  Fly   300 RNLLHQNATLMERSEVIFGRLEAAGC---GSPLPQLPFWQCFLTVTGKLYVPGGSGRAGGSLAQG 361
                        |:.|..|||   ||   ..|                  :.|..||..|
Mouse   166 ------------RAYVQDGRL---GCTRESDP------------------ILGPDGRTHG----- 192

  Fly   362 RISGQGGSLAEPNHLGMDAAKRQCCEQASSHKCRRLCNQIFTSNWWDARSSFENECMDQPGEREL 426
                                          ::| .:|.::|      .:.:.||...::  |..:
Mouse   193 ------------------------------NRC-AMCAELF------LKEAKENATRNR--ESRI 218

  Fly   427 RRCIESVDAPCELGCQGLSFCSNFNN--RPTELFRSCTPEHDAAAREDWQLLQQRGTVRVLGQEL 489
            ||     ||..||       |..|.|  |...||  ||.|.|.....|.::   .|....|..|:
Mouse   219 RR-----DAEKEL-------CKEFENQVRNGRLF--CTRESDPIRGPDGKM---HGNKCALCAEI 266

  Fly   490 FIK----------NTSRCAPDKWRALVCALQLKPCTRVGLFNGICSEDCHELLDECLDWTLQHQR 544
            |::          ...:.|.::.:|   .::::             :.|.|..|...:.||...|
Mouse   267 FMRQFTEEKGKAEKNQKDAEERAKA---KMEIQ-------------KRCSEFQDRARNGTLFCTR 315

  Fly   545 PKDICSRLKEKDDDDSPLPC---ISLESYLKPGDA------SPEEFQGITSPC-----AQKPCNG 595
            ..|....|..|...:....|   ...|:..|..:|      ..||.:.....|     |:|  ||
Mouse   316 ENDPIRGLDGKTHGNLCSMCQAFFKTEAEEKKAEAGSRNRRGSEESETYAKLCDEYRKARK--NG 378

  Fly   596 SEVCILQ----RG------GNQGYSCIPGCNLGQDSKLFVPFGSYVRLGKSNLHKKLEVGQFPLA 650
            ...|..:    ||      ||.       |::.|        ..:::..|:....|.|..:
Mouse   379 QLYCTRENAPIRGPDGKIHGNT-------CSMCQ--------AFFIQEDKARAKVKREAAK---- 424

  Fly   651 EHIVCSCGLQGRLEQCQPLPSYMH---AHCT-----LPGARSYRHGSSFYLECNLC-SCFAGEIT 706
                         |.|....:...   ..||     :.|....||.:    :|.:| |.|..|..
Mouse   425 -------------EMCSEFRNQARNGMLMCTRENDPVVGPDGKRHSN----KCAMCASVFLLEEE 472

  Fly   707 CTKQQCRLPGFVDSG--------------YTSL---PCNCPAHYVPVCGSNGNTYPSACVAKCHL 754
            ..|:..:... ||:|              :|.|   |..|.....|:.|.:|..|.:||
Mouse   473 EKKKDDKTEK-VDAGKAKKEAVQELCRKYHTQLRNGPLRCTRRNNPIEGLDGKMYKNAC------ 530

  Fly   755 PEGDYVYGACNARNACQAAPPNSCPSGTQCLDSRKVCLASMQRPCLQYVCVNATASNCSTFHQGE 819
                ::..|...:.|.::.      :|.:....|:|     :..|.:|:.::.......|.....
Mouse   531 ----FMCWAFFQQEAKKSG------AGFRPKVKREV-----KVDCSEYLALSKRGEIFCTRENDP 580

  Fly   820 VCDSQGRTYPNACALLKA----------------------------NPQGQ---VAYWSACQSSR 853
            |....|:|:.|.||:.||                            ||:.:   ..|..:.:..:
Mouse   581 VRGPDGKTHGNKCAMCKAVFKKENEERKRKEGENQRITSGESSSGGNPKAKDECAQYRESMKHGQ 645

  Fly   854 FNTS--PSPVCGINGVTYKS 871
            .:.:  ..||.|::|..|.:
Mouse   646 LSCTRESDPVRGVDGEHYNN 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reck	NP_001261853.1	KAZAL_FS	729..>753	CDD:238052	7/23 (30%)
Spink5	NP_001074649.1	KAZAL_PSTI	108..152	CDD:238648	11/44 (25%)
		KAZAL_FS	176..>200	CDD:381802	8/77 (10%)
		KAZAL	240..275	CDD:197624	10/39 (26%)
		KAZAL	312..351	CDD:197624	7/38 (18%)
		KAZAL_FS	441..>464	CDD:381802	6/26 (23%)
		KAZAL	573..613	CDD:197624	9/39 (23%)
		KAZAL_FS	648..>672	CDD:381802	5/17 (29%)
		KAZAL_FS	715..>740	CDD:381802
		KAZAL_FS	783..821	CDD:381802
		KAZAL_PSTI	953..996	CDD:238648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810