DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reck and Reck

DIOPT Version :9

Sequence 1:	NP_001261853.1	Gene:	Reck / 39629	FlyBaseID:	FBgn0036463	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_057887.2	Gene:	Reck / 53614	MGIID:	1855698	Length:	971	Species:	Mus musculus

Alignment Length:	1013	Identity:	340/1013 - (33%)
Similarity:	516/1013 - (50%)	Gaps:	132/1013 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 SPGESYDIFTCCNQVFGS--CRTACENLSLVEFATGTGGDNRDELHR---YCQLHQVEFWTCVNQ 163
            :||.:..:  |||....:  ||..||.:    |::.:....:..|.|   ||....||.|:|:|.
Mouse    29 APGSAGAV--CCNHSKDNQMCRDVCEQI----FSSKSESRLKHLLQRAPDYCPETMVEIWSCMNS 87

  Fly   164 TFDAITRGAD-WSGRRCCQFGVLPHCRNVC--ATSTRSPVQNCRRSDEQTLYDCLERQEAADQCC 225
            :...:.:.:| |.|..||:..:...||..|  |:|.....:.||:..|..|:.|:.|.|....||
Mouse    88 SLPGVFKKSDGWVGLGCCELAIGLECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCC 152

  Fly   226 GQA-RTSECLEACRAVFE----------PANDNHDHVDINGACGDRNADVIQCVNNHTDMTPLAN 279
            ..| ..:.|.|.|:|:|.          .|.:|:        |...:..:|.||||:|...|:.|
Mouse   153 SYAGHHTNCREFCQAIFRTDSSPGPSQIKAVENY--------CASISPQLIHCVNNYTQSYPMRN 209

  Fly   280 AEQYIPCCEYSSKEHCRHTCRNLLHQNATLMERSEVIFGRLEAAGCGS-PLPQLPFWQCFLTVTG 343
            ....:.||:.:....|::.|:.:|....|.|   |::.|.:|  ||.: ||||.|.|||||..:.
Mouse   210 PTDSLYCCDRAEDHACQNACKRILMSKKTEM---EIVDGLIE--GCKTQPLPQDPLWQCFLESSQ 269

  Fly   344 KLYVPGGSGRAGGSLAQGRISGQGGSLAEPNHLGMDAAKRQCCEQASSHKCRRLCNQIFTSNWWD 408
            .::                   .|.::..|...|:|.||..||.:|::..||.||.::::.:|.:
Mouse   270 SVH-------------------PGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGN 315

  Fly   409 ARS--SFENECMDQPGERELRRCIESVDAPCELGCQGLSFCSNFNNRPTELFRSCTPEHDAAARE 471
            .:|  .|:..|...|.|..:..|:..|..||:|||..|::|:||||||||||||||.:.|..|..
Mouse   316 TQSWQEFDRICEYNPVEVSMLTCLADVREPCQLGCTNLTYCTNFNNRPTELFRSCTAQSDQGAMS 380

  Fly   472 DWQLLQQRGTVRVLGQELFIKNTSRCAPDKWRALVCALQLKPCTRVGLFNGICSEDCHELLDECL 536
            |.: |.::|::::....:.:.:...|.|:.|:|:.|:||:|||......:.||..||.|:|.:|.
Mouse   381 DMK-LWEKGSIKMPFISIPVLDIKTCQPEMWKAVACSLQIKPCHSKSRGSIICKSDCVEILKKCG 444

  Fly   537 DWTLQHQRPKD-----ICSRLKEKDDDDSPLPCISLESYLKPGDASPEEFQGITSPCAQKPCNGS 596
            |   |::.|::     ||..|...||.:|   ||.|::||:| .|.....:.:|.||...||..:
Mouse   445 D---QNKFPEEHTAESICEFLSPADDLES---CIPLDTYLRP-SALGNIIEEVTHPCNPNPCPAN 502

  Fly   597 EVCILQRGGNQG------YSCIPGCNLGQDSKLFVPFGSYVRLGKSNLHKKLEVGQFPLAEHIVC 655
            |:|.:.|.|...      |||:.||.||:.|...|..|:.:::..|    ..|||.:.     :|
Mouse   503 ELCEVNRKGCPSADPCLPYSCVQGCKLGEASDFIVRQGTLIQVPSS----AGEVGCYK-----IC 558

  Fly   656 SCGLQGRLEQCQPLPSYMHAHC------TLPGARSYRHGSSFYLECNLCSCFAGEITCTKQQCRL 714
            |||..|.||.|      |..||      .:.|.:...||:||.::||:||||||.:.|:.:.|..
Mouse   559 SCGQSGLLENC------MEMHCIDLQKSCIVGGKRKSHGTSFTIDCNVCSCFAGNLVCSTRLCLS 617

  Fly   715 PGFVDSG---YTSLPCNCPAHYVPVCGSNGNTYPSACVAKC-HLPEGDYVYGACNARNACQAAPP 775
            ....|..   :|.|||||...:||||..||.||||||:|:| .|.:..:.:|.|.::|.|.   |
Mouse   618 EHSSDDDRRTFTGLPCNCADQFVPVCAQNGRTYPSACIARCVGLQDHQFEFGPCISKNPCN---P 679

  Fly   776 NSCPSGTQCLDSRKVCLASMQR-PCLQYVCVNATASNCSTFHQGEVCDSQGRTYPNACALLKANP 839
            |.||...:|:...:|||.:..: .|.||.||....: |.. .:..|||:....:.|.|.|.:...
Mouse   680 NLCPKSQRCVPKPQVCLTTFDKFGCSQYECVPRQLT-CDQ-ARDPVCDTDHMEHSNLCTLYQRGK 742

  Fly   840 QGQVAYWSACQSSRFNTSPSPVCGINGVTYKSSYAARAEYVLVDYVGRCREVGLLVSDMG--RRC 902
              .::|...||.  |..:..||||.||.||.|..||.::.|.|||.|.|:.||:| |:..  ..|
Mouse   743 --SLSYRGPCQP--FCRAKEPVCGHNGETYSSVCAAYSDRVAVDYYGPCQAVGVL-SEYSAVAEC 802

  Fly   903 RTVKCPAPVSKHCRLIVPPGACCPLCAGGAFRIIYSRKQFDRAMYGLRAQSSTLLTLQGVLQQLD 967
            ..||||:..:..|:.|:|||||||||| |..|:::.:::.|..   .:..|...:|:..:||::.
Mouse   803 AAVKCPSLSAIGCKPIIPPGACCPLCA-GMLRVLFDKEKLDTI---AKVTSKKPITVVEILQKVR 863

  Fly   968 GLVQVSECQLTGFLTMEVGIFVAIVPSSSIKRPTHLQLEACAREAEKISSLINAQSPRITTNLAL 1032
            ..|.|.:|.:.|:|::|..|.:.|:|....  |..||:|||.:|||||.||||:.||.:.:::.|
Mouse   864 MHVSVPQCDVFGYLSIESEIVILIIPVDHY--PKALQIEACNKEAEKIESLINSDSPTLASHVPL 926

  Fly  1033 SCLTVS--HLLEPTPNGATSYGP--HAIWILPLLLLVS 1066
            |.|.:|  .:....|:.|....|  |:     ||||:|
Mouse   927 SALIISQVQVSSSLPSSAVVGRPLFHS-----LLLLLS 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reck	NP_001261853.1	KAZAL_FS	729..>753	CDD:238052	15/24 (63%)
Reck	NP_057887.2	5 X Knot repeats	37..338		90/322 (28%)
Reck	NP_057887.2	Amnionless	<802..>867	CDD:291494	29/66 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833053
Domainoid	1	1.000	342	1.000	Domainoid score	I1073
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9622
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1142
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49635
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007351
OrthoInspector	1	1.000	-	-		oto95073
orthoMCL	1	0.900	-	-		OOG6_108997
Panther	1	1.100	-	-	LDO	PTHR13487
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5670
SonicParanoid	1	1.000	-	-		X5473
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790