DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reck and Reck

DIOPT Version :9

Sequence 1:	NP_001261853.1	Gene:	Reck / 39629	FlyBaseID:	FBgn0036463	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	XP_006238130.1	Gene:	Reck / 313488	RGDID:	1308845	Length:	972	Species:	Rattus norvegicus

Alignment Length:	1020	Identity:	340/1020 - (33%)
Similarity:	517/1020 - (50%)	Gaps:	123/1020 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 IDSSEVTAVESIRSPGESYDIFTCCNQVFGS--CRTACENLSLVEFATGTGGDNRDELHR---YC 150
            :.::.|..|....:||.:..:  |||....:  ||..||.:    |::.:....:..|.|   ||
  Rat    16 LSAAGVAKVTGGLAPGSAGAV--CCNHSKDNQMCRDVCEQI----FSSKSESRLKHLLQRAPDYC 74

  Fly   151 QLHQVEFWTCVNQTFDAITRGAD-WSGRRCCQFGVLPHCRNVC--ATSTRSPVQNCRRSDEQTLY 212
            ....||.|:|:|.:...:.:.:| |.|..||:..:...||..|  |:|.....:.||:..|..|:
  Rat    75 PETMVEIWSCMNSSLPGVFKKSDGWVGLGCCELAIGLECRQACKQASSKNDISKVCRKEYENALF 139

  Fly   213 DCLERQEAADQCCGQA-RTSECLEACRAVFE----------PANDNHDHVDINGACGDRNADVIQ 266
            .|:.|.|....||..| ..:.|.|.|:|:|.          .|.:|:        |...:..:|.
  Rat   140 SCISRNEMGSVCCSYAGHHTNCREFCQAIFRTDSSPGPSQIKAVENY--------CASISPQLIH 196

  Fly   267 CVNNHTDMTPLANAEQYIPCCEYSSKEHCRHTCRNLLHQNATLMERSEVIFGRLEAAGCGS-PLP 330
            ||||:|...|:.|....:.||:.:.:..|:..||.:|....|.|   |::.|.:|  ||.: |||
  Rat   197 CVNNYTQSYPMRNPTDSLYCCDRAEEHACQSACRRILTSKKTEM---EIVDGLIE--GCKTQPLP 256

  Fly   331 QLPFWQCFLTVTGKLYVPGGSGRAGGSLAQGRISGQGGSLAEPNHLGMDAAKRQCCEQASSHKCR 395
            |.|.|||||..:..::                   .|.::..|...|:|.||..||.:|::..||
  Rat   257 QDPLWQCFLESSQSVH-------------------PGVTVHPPPSTGLDGAKLHCCSKANTSVCR 302

  Fly   396 RLCNQIFTSNWWDARS--SFENECMDQPGERELRRCIESVDAPCELGCQGLSFCSNFNNRPTELF 458
            .||.::::.:|.:.:|  .|:..|...|||..:..|:..|..||:|||..|::|:||||||||||
  Rat   303 ELCTKLYSMSWGNTQSWQEFDRICEYNPGEVSMLACLADVREPCQLGCTNLTYCTNFNNRPTELF 367

  Fly   459 RSCTPEHDAAAREDWQLLQQRGTVRVLGQELFIKNTSRCAPDKWRALVCALQLKPCTRVGLFNGI 523
            ||||.:.|..|..|.: |.::|::::....:.:.:...|.||.|:|:.|:||:|||.|....:.|
  Rat   368 RSCTAQSDQGAMSDMR-LWEKGSIKMPFISIPVLDIRTCQPDLWKAVACSLQIKPCHRKSRGSII 431

  Fly   524 CSEDCHELLDECLDWTLQHQRP-----KDICSRLKEKDDDDSPLPCISLESYLKPGDASPEEFQG 583
            |..||.|:|.:|.|   |::.|     :.||..|...||.::   ||.|::||:| .|.....:.
  Rat   432 CKSDCVEILKKCGD---QNKFPEAHTAESICEFLSPADDVEN---CIPLDTYLRP-SALGNIIEE 489

  Fly   584 ITSPCAQKPCNGSEVCILQRGGNQG------YSCIPGCNLGQDSKLFVPFGSYVRLGKSNLHKKL 642
            :|.||...||..:|:|.:.|.|...      |||:.||.||:.|...|..|:.:::..|    ..
  Rat   490 VTHPCNPNPCPANELCEVNRKGCPSGDPCLPYSCVQGCKLGEASDFIVRQGALIQVPSS----AG 550

  Fly   643 EVGQFPLAEHIVCSCGLQGRLEQCQPLPSYMHAHC------TLPGARSYRHGSSFYLECNLCSCF 701
            |||.:.     :||||..|.||.|      |..||      .:.|.:...||:||.::||:||||
  Rat   551 EVGCYK-----ICSCGQSGLLENC------MEMHCIDLQKSCIVGGKRKSHGTSFTIDCNVCSCF 604

  Fly   702 AGEITCTKQQCRLPGFVDS---GYTSLPCNCPAHYVPVCGSNGNTYPSACVAKC-HLPEGDYVYG 762
            ||.:.|:.:.|......|.   .:|.|||||...:||||..||.||||||:|:| .|.:..:.:|
  Rat   605 AGNLVCSTRLCLSEHSSDDDRRAFTGLPCNCADQFVPVCAQNGRTYPSACIARCVGLQDHQFEFG 669

  Fly   763 ACNARNACQAAPPNSCPSGTQCLDSRKVCLASMQR-PCLQYVCVNATASNCSTFHQGEVCDSQGR 826
            .|.:::.|.   ||.||...:|:...:|||.:..: .|.||.||....: |.. .:..|||:...
  Rat   670 PCISKDPCN---PNLCPKSQRCVPKPQVCLTTFDKFGCSQYECVPRQLT-CDQ-ARDPVCDTDHV 729

  Fly   827 TYPNACALLKANPQGQVAYWSACQSSRFNTSPSPVCGINGVTYKSSYAARAEYVLVDYVGRCREV 891
            .:.|.|.|.:...  .::|...||.  |..:..||||.||.||.|..||.::.|.|||.|||:.|
  Rat   730 EHSNLCTLYQRGK--SLSYRGPCQP--FCRTTEPVCGHNGETYSSVCAAYSDRVAVDYYGRCQAV 790

  Fly   892 GLLVSDMG-RRCRTVKCPAPVSKHCRLIVPPGACCPLCAGGAFRIIYSRKQFDRAMYGLRAQSST 955
            |:|..... ..|..||||:..:..|:.|:|||||||||| |..|:::.:::.|..   .:..:..
  Rat   791 GVLSEHSAVTECAAVKCPSLSAIGCKPIIPPGACCPLCA-GMLRVLFDKEKLDTI---AKVTNKK 851

  Fly   956 LLTLQGVLQQLDGLVQVSECQLTGFLTMEVGIFVAIVPSSSIKRPTHLQLEACAREAEKISSLIN 1020
            .:|:..:||::...|.|.:|.:.|:|::|..|.:.|:|....  |..||:|||.:|||||.||||
  Rat   852 PITVLEILQKIRMHVSVPQCDVFGYLSIESEIVILIIPVDHY--PKALQIEACNKEAEKIESLIN 914

  Fly  1021 AQSPRITTNLALSCLTVS--HLLEPTPNGATSYGPHAIWILPLLL 1063
            :.||.:.:::.||.|.:|  .:....|:.|.......:..|||.|
  Rat   915 SDSPTLASHVPLSALIISQVQVSSSLPSSAVVGRLPPVHSLPLFL 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reck	NP_001261853.1	KAZAL_FS	729..>753	CDD:238052	15/24 (63%)
Reck	XP_006238130.1	Amnionless	<802..>867	CDD:291494	29/65 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336633
Domainoid	1	1.000	349	1.000	Domainoid score	I995
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9622
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1076
OMA	1	1.010	-	-		QHG49635
OrthoDB	1	1.010	-	-		D279140at33208
OrthoFinder	1	1.000	-	-		FOG0007351
OrthoInspector	1	1.000	-	-		oto98567
orthoMCL	1	0.900	-	-		OOG6_108997
Panther	1	1.100	-	-	LDO	PTHR13487
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5473
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810