DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reck and Fs

DIOPT Version :9

Sequence 1:	NP_001261853.1	Gene:	Reck / 39629	FlyBaseID:	FBgn0036463	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster

Alignment Length:	998	Identity:	192/998 - (19%)
Similarity:	295/998 - (29%)	Gaps:	404/998 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 HHRHAPSSGSKKNSRSHSVSLDSDDYDWLDADTSEAIDS--SEVTAVESIRS-PGESYDIFTCCN 116
            ||:|.|:|     |:::...|.| :|.:.....|.||.:  :..|..|:.|: |.::.|
  Fly     5 HHQHQPTS-----SQNNLTFLKS-NYKFKRRAMSMAIRALPATTTPAEARRAEPSQNTD------ 57

  Fly   117 QVFGSCRTACENLSLVEFATGTGGDNRDELHRYCQLHQVEFWTCVNQTFDAITRGADWSGRRCCQ 181
                   .....:|....||.|                        |...|.:|
  Fly    58 -------QLAATMSKTSAATAT------------------------QLARATSR----------- 80

  Fly   182 FGVLPHCRN------VCATSTRSPVQNCRRSDEQTLYDCLERQEAADQCCGQARTSECLEACRAV 240
                 .||.      |.|.|....:.||.|.||             |:..|..|
  Fly    81 -----ECRTILGLFIVSAWSALQELANCLRQDE-------------DRYVGHGR----------- 116

  Fly   241 FEPANDNHDHVDINGACGDRNADVIQCVNNHTDMTPLANAEQYIPCCEYSSKEHCRHTCRNLLHQ 305
                       |:|.:            ::.:|...:|..:|      ...::|.:|
  Fly   117 -----------DVNAS------------SDASDEVSMAREQQ------QHQRQHSKH-------- 144

  Fly   306 NATLMERSEVIFGRLEAAGCGSPLPQLPFWQCFLTVTGKLYVPGGSGRAGGSLAQGRISGQ--GG 368
            :|:......:...|.:||...               ||   ....:...|.:.|:|..||.  ||
  Fly   145 SASSSPAKSMRCTRAKAASAS---------------TG---TAAATATLGAAAAEGATSGHQLGG 191

  Fly   369 SLAEPNHLGM------DAAKRQCCEQASSHKCRRLCNQIFTSNWWDARSSFENECMDQP-----G 422
            .......:|:      .||...|.:   :|.....|.|:|:::  .:||    ||....     .
  Fly   192 QPLMALLIGLLLLNFRLAAAGTCWQ---THLGSGKCGQVFSTD--ISRS----ECCGSSQSFSYT 247

  Fly   423 ERELRRCIESVD-------------APCELGCQGLSF-----CSNFNNRPTELFRSCTPEHDAAA 469
            :|||    .||:             :||...|:|...     |.....||..:   |.||..||.
  Fly   248 DREL----SSVEYFFATAIGGGVECSPCMESCKGFKCGPNKKCVKRKGRPKCV---CAPECGAAL 305

  Fly   470 REDWQLLQQRGTVRVLGQELFIKNTSRCAPDKWRALVCALQLKPCTRVGLFNGICSEDCHELLDE 534
            |.           |...|||.::.......::       .::||           ..:...|..|
  Fly   306 RR-----------RTHQQELELEQEPELEEEQ-------QEMKP-----------PRESRSLSSE 341

  Fly   535 CLDWTL-----QHQR--------PKDICSR----LKEKDDDDSPLP---------CISLESYLK- 572
            ..::.|     |.||        |::...|    :.......|.||         .:.:..|.:
  Fly   342 NTNFNLGLDGGQRQRADNQRKLQPRESKHRRLLIIDSSSRSSSNLPDQPTSGRRGRVEMTGYERR 406

  Fly   573 ----------------------PGDASPEEFQGITSPCAQKPCNGSEVCILQRGGNQGYSCIPGC 615
                                  |.|.:|          ||.|...| :....|..|...:..|..
  Fly   407 RHRNNHGKHLTRSMTTGANDSFPADKTP----------AQSPAADS-ILAQSRLANLANANEPAN 460

  Fly   616 NLGQDSKLFVPFGSYVRLGKSNLHKKLEVGQFPLAEHIVCSCGLQGRLEQCQPLPSYMH------ 674
            ::.:.|...|         :....:::|....|       ..||:.|..:.|....:.|
  Fly   461 DINRQSSTRV---------RHQHARRIEHAPNP-------DNGLRKRQHKQQQQHQHQHQDRMNT 509

  Fly   675 ----AHCTLPGARS----------YRHGSSFYLECNLCSCFAGEITCTKQQCRLPGFVDSGYTSL 725
                |:.|:.|:.|          .:|||.        :..:.::..|.....|.|.    |..|
  Fly   510 EAQSANTTVSGSGSGATNHRRISQLQHGSE--------TAASSDLANTHDLAHLGGI----YAPL 562

  Fly   726 PCNCPAHYVPVCGSNGNTYPSACVAKCHLPEGDYVYGACNARNA---------CQAAPPNSCPSG 781
            |   |.|..||||::|.||.:.|..:..         ||...||         |:    ||| ||
  Fly   563 P---PQHSNPVCGTDGRTYNTECQLRKR---------ACRTNNAQLEVAYRGHCK----NSC-SG 610

  Fly   782 TQCLDSRKVCLASMQRPCLQYVCV---------NATASNCSTFHQGEVCDSQGRTYPNAC----A 833
            ..||:.    |..::...|...|:         |....:.....:..||...|:||.:||    .
  Fly   611 VHCLNG----LTCVEDQYLMPHCIACRIECPWDNLDVDSSGYDERQAVCGVDGKTYRSACDINRM 671

  Fly   834 LLKANPQGQVAYWSACQSSRFNTSPSPVCGINGVTYKSSYAARAEYVLVDYVGRCREVGLLVSDM 898
            :.|......|||...|::.|.:.:... ||            ..:..|||...|
  Fly   672 ICKIGRSIAVAYPGPCRAGRVSCADIK-CG------------PKDNCLVDLQTR----------- 712

  Fly   899 GRRCRT--VKCP----APVSKHC 915
            ..||.|  .|||    .||.|.|
  Fly   713 QPRCVTCRYKCPRKQQRPVHKIC 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reck	NP_001261853.1	KAZAL_FS	729..>753	CDD:238052	10/23 (43%)
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	14/48 (29%)
		KAZAL_FS	654..687	CDD:238052	11/32 (34%)
		KAZAL_FS	723..767	CDD:238052	6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900