DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zip71B and slc39a14

DIOPT Version :9

Sequence 1:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001313628.1	Gene:	slc39a14 / 799782	ZFINID:	ZDB-GENE-060315-2	Length:	494	Species:	Danio rerio

Alignment Length:	574	Identity:	147/574 - (25%)
Similarity:	236/574 - (41%)	Gaps:	174/574 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AQIFQ----KYGNGGTINFEGLEHLMFSLNLGQIQFDPSHTIDQHRPQGYSNEMPHATNVTYYFE 93
            ||:.|    :||:..:|:...|..|:..||.||.:...|.|                       :
Zfish    41 AQVLQELLTRYGDNASISVPQLRSLLVRLNGGQSEDHDSKT-----------------------Q 82

  Fly    94 PTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDPKHRHPRESSEPVAACLSPKSLLSLI 158
            |||.||                                              :.||:..:|
Zfish    83 PTRTNA----------------------------------------------SKCLAADTL---- 97

  Fly   159 VNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNEFINSVRITPRAFMKLCPALLAQIDNGVCK 223
                                     .|:...|:       .||..|...::||.::.|:|:..||
Zfish    98 -------------------------AVYGMSEQ-------SRIDERGLQQICPTMIQQLDSQACK 130

  Fly   224 -QPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVPLMKSAAYQEILKFLVSIAVGTL 287
             ||...|.:.....:.  ..|.|..:.:.::|.|.|:|..:||.|:...|:.:|.:.:::|:|||
Zfish   131 TQPNQESESSPRPTEA--EVWGYGLLCVTVISLCSLVGASVVPFMRKTFYKRLLLYFIALAIGTL 193

  Fly   288 AGDALMHLLPHALFKEEKHEEEVTGINPLESDHKHSNEAALLCGCTFLAALFMYMLENLIPLLKG 352
            ..:||..|:|.|.           |.:|:| |: :..::|::.|..:|    .:..|.::.::.
Zfish   194 YSNALFQLIPEAF-----------GFDPME-DY-YVPKSAVVFGGFYL----FFFTEKILKMIL- 240

  Fly   353 GKPGHGHSHGHGHSH------GRSHGH-----MEKPAAKDAIDLPPPR---------ELNVMLQE 397
             ||.....|||||||      ..|:|.     |||....:|.....||         |.:.||..
Zfish   241 -KPKDTGGHGHGHSHFPAERYANSNGDLEDGVMEKLQNGEAGGAALPRAEADGRGVGEDDKMLST 304

  Fly   398 AKLDEKTPD-----------------RPLTPVAFMVIIGDGLHNLTDGLAIGAAFASDPVTGFAT 445
            .:..:.|..                 ..:..:|:|:.:.|||||..|||||||:|.:....|.:|
Zfish   305 GQTVQDTQSSGGGGTGGCYWLKGRAYSDIGTLAWMITLSDGLHNFIDGLAIGASFTASVFQGIST 369

  Fly   446 AFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGIGDGMTQWIYAAT 510
            :.|:||.|.|||||||.:||..|:|:::|::.|.:|:...::||..|: :|| .:....||:|..
Zfish   370 SVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGMGFGI-LAG-NNFSPNWIFALA 432

  Fly   511 AGSFLYIAFADLVPTMSVAHNPEKAKDPKGII----IQIFGILLGGLIMLAIAL 560
            .|.|||||.||:.|.|:.....|:.....|.:    :|..|:|.|..|||.:.:
Zfish   433 GGMFLYIALADMFPEMNEVSREEEEAGGSGFLLTFALQNAGLLTGFAIMLVLTI 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	111/357 (31%)
slc39a14	NP_001313628.1	Zip	146..485	CDD:308248	111/361 (31%)
		HHHGHXHX-motif. /evidence=ECO:0000250\|UniProtKB:Q15043	248..255		6/6 (100%)
		XEXPHE-motif. /evidence=ECO:0000250\|UniProtKB:Q15043	376..381		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107054
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920