DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zip71B and Slc39a4

DIOPT Version :9

Sequence 1:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_082340.1	Gene:	Slc39a4 / 72027	MGIID:	1919277	Length:	660	Species:	Mus musculus

Alignment Length:	595	Identity:	165/595 - (27%)
Similarity:	264/595 - (44%)	Gaps:	163/595 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLNLFCLGSLFFKTVPASTEYNKYVAQIFQKYGNG-GTINFEGLEHLMFSLNLGQIQFDPSHTID 71
            |:|..|     |:.:| |.:|  :|..:|:.:.:. ..|....||:||..|.:|    ...|:
Mouse   190 VINGSC-----FQGLP-SPQY--FVDFVFRLHSSDPPNITLHELENLMHHLGVG----GEDHS-- 240

  Fly    72 QHRPQGYSNEMPHATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDPKHR 136
            .|...|...:..|         |.|               :.:|.:|          |:|.|
Mouse   241 DHDDHGDHADHSH---------PDR---------------KASHQDS----------ELHTP--- 268

  Fly   137 HPRESSEPVAACLSPKSLLSLIVNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNEFINSVRI 201
            |...||.....|||.|.:::                            |:...||       ..:
Mouse   269 HNSNSSVWDTLCLSAKDIMA----------------------------VYGLSEE-------AGV 298

  Fly   202 TPRAFMKLCPALLAQIDNGVCK-QPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVP 265
            :|:|:.:|.|||:.|..:|.|. .|.:|..:...:.::    ::|.|:..|::..|.:.|:||:.
Mouse   299 SPQAWAQLTPALVQQQLSGACSPYPTIRIQDQLSQTER----YLYGSLATLLICLCAVFGLLLLT 359

  Fly   266 LMK-SAAYQEILKFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPLESD-HKHSNEAAL 328
            ..| |.|...|::..:|:|||.|.||||:||:|           :|.|::....: |.|..|..:
Mouse   360 CAKCSTATHYIMQTFLSLAVGALTGDALLHLIP-----------KVLGLHTHGGEGHTHEEEVGV 413

  Fly   329 LCGCTF--LAAL----FMYMLENLIPLL--------KGGKPGHGHSHGHGHSHGRSHGHMEKPAA 379
            ....|:  ||.|    ..::.|:...||        |.|...||     |||||.|
Mouse   414 GGQATWRLLAVLGGFYIFFLFESFFNLLLPRDQDSEKDGPCSHG-----GHSHGIS--------- 464

  Fly   380 KDAIDLPPP--RELNVMLQEAKLD---EKTPDRPLTP-----------VAFMVIIGDGLHNLTDG 428
               :.|.|.  |:.....:.::.|   |:||:. |.|           :.:::.:||.:||..||
Mouse   465 ---LQLAPSNLRQSKQTHESSRSDLVAEETPEL-LNPETRRLRAELRLLPYLITLGDAVHNFADG 525

  Fly   429 LAIGAAFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGL 493
            ||:||||:|...||.||:.||.||||||||||||.||..|:|::||:.:|:.|::.:|.|:.|.|
Mouse   526 LAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVKRALLLNLASALTAFAGLYVAL 590

  Fly   494 FIAGIGDGMTQWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKG---IIIQIFGILLGGLIM 555
            .: |:|:....||.|...|.|||:|..|::|.|.      ..:|.:.   .::...|:|.|..::
Mouse   591 AV-GVGEEGEAWILAVATGLFLYVALCDMLPAMM------NVRDQRPWLLFLLHNVGLLGGWTVL 648

  Fly   556 LAIALNEHDL 565
            |.::|.|.::
Mouse   649 LLLSLYEDNI 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	115/351 (33%)
Slc39a4	NP_082340.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..273		13/82 (16%)
Slc39a4	NP_082340.1	Zip	338..651	CDD:280666	115/348 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43177
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050