DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zip71B and Slc39a5

DIOPT Version :9

Sequence 1:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001129709.1	Gene:	Slc39a5 / 72002	MGIID:	1919336	Length:	535	Species:	Mus musculus

Alignment Length:	582	Identity:	184/582 - (31%)
Similarity:	280/582 - (48%)	Gaps:	122/582 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSHTIDQHRPQGYSNEMPHATN 87
            ||..|.|.|:||:|..||..||:...||..|:.||.||::|   ...:..|.|...........|
Mouse    30 PAEQEQNHYLAQLFGLYGENGTLTAGGLARLLHSLGLGRVQ---GLRLGHHEPPTGRAAPTSGDN 91

  Fly    88 VTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDPKHRHPRESSEPVAACLSPK 152
            .|:..:...::......:.|..|..|:    |.|::.|   ::|..                .|.
Mouse    92 FTHRLQEPELSVDIWAGMPLGPSGWGD----QEESKAP---DLHGS----------------GPS 133

  Fly   153 SLLSLIVNHNDLHKNIAYRKLLIKN----DVSSTDGVHNSEEEYNEFINSVR-ITPRAFMKLCPA 212
            ||        ||     :::||:.:    |..:.|.::.|:...|..::.|. :|||.|..||||
Mouse   134 SL--------DL-----FQRLLLLDHSLADHLNEDCLNGSQLLVNFGLSPVAPLTPRQFALLCPA 185

  Fly   213 LLAQIDNGVC-KQPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVPLMKSAAYQEIL 276
            ||.|||:.|| |.||.....      .:..|.:::.:.:|.||....|.:||:.|:.....:.:|
Mouse   186 LLYQIDSRVCIKTPAPAPPG------DVLSALLHSGLAVLFLSLPAPLSLLLLRLLGPRLLRPVL 244

  Fly   277 KFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPLESDHKHSNEAALLCGCTFLAALF-M 340
            .||.::|||||.||||:||||||  :..:|    ||  |.|     .:|..|..|.:.|..|| :
Mouse   245 GFLGALAVGTLCGDALLHLLPHA--QGGRH----TG--PSE-----QSEEDLGPGLSVLGGLFLL 296

  Fly   341 YMLENLIPLLKGGKPGHGHSHGHGHSHGRSHGHMEKPAAKDAIDL----PPPRELNVML------ 395
            :||||.:.|::                   |..:.....::..||    |.|.:.:.|:
Mouse   297 FMLENTLGLVR-------------------HRGLRPRCCRNKRDLGEPNPDPEDGSGMVLRPLQA 342

  Fly   396 -QEAKLDEKTPDRPLTP------------------VAFMVIIGDGLHNLTDGLAIGAAFASDPVT 441
             .|.::..:..:|..:|                  :|:||::||.|||||||||:||||:....:
Mouse   343 ASEPEVQGQRENRQSSPSLAPPGHQGHSHEHRGGSIAWMVLLGDCLHNLTDGLALGAAFSDGFSS 407

  Fly   442 GFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGIGDG---MT 503
            |.:|..||.||||||||||||:|||.|:|.|:.:.:::||..|...|.::|:   |:..|   :|
Mouse   408 GLSTTLAVFCHELPHELGDFAMLLQEGLSFRKLLLLSLVSGALGLGGAALGV---GLSLGPVPLT 469

  Fly   504 QWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKGIIIQIFGILLGGLIMLAIALNEHDL 565
            .|::..|||.|||:|..|::||:.   .|.:......:::|..|:||||.:|..|||.|..|
Mouse   470 PWVFGTTAGVFLYVALVDMLPTLL---RPPEPLPVFHVLLQGLGLLLGGSLMFTIALLEEQL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	118/349 (34%)
Slc39a5	NP_001129709.1	Zip	243..499	CDD:308248	103/293 (35%)
Slc39a5	NP_001129709.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..373		8/56 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833480
Domainoid	1	1.000	59	1.000	Domainoid score	I10640
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	1	1.000	-	-		FOG0007810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850