Protein Alignment Zip71B and SLC39A10

DIOPT Version :9

• Sequence 1: NP_001097608.1
• Gene: Zip71B / 39626
• FlyBaseID: FBgn0036461
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001120729.1
• Gene: SLC39A10 / 57181
• HGNCID: 20861
• Length: 831
• Species: Homo sapiens
• Alignment Length: 816
• Identity: 196/816 - (24%)
• Similarity: 303/816 - (37%)
• Gaps: 316/816 - (38%)

  Fly    19 FKTVPASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQ---------------------- 61
            |....|..|...|:.::|::||..|.::|.|||.|:.:|.||:
Human    51 FSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDIL 115

  Fly    62 ------------------------------------------------IQFDPSHTIDQHRPQGY 78
                                                            ::.|..|..|.:....:
Human   116 AVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRH 180

  Fly    79 SNEMPHAT--NVTYYF---------------EP-TRVNATDEEALELQI-----SPRGNHSNSQS 120
            .:.:.|..  |.|::|               || |..|.|.|:: ::::     ..:|..||..|
Human   181 HHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQS-DVKLPKGKRKKKGRKSNENS 244

  Fly   121 EAEVPEFL------------------EIHDPKHRH----PRESSEPVAACLSPKSLLSLIVNHND 163
            |...|.|.                  .:|:|.|.|    .|...:|..             .|.|
Human   245 EVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGR-------------GHQD 296

  Fly   164 LH------------------KNIAYRKLLIKNDVSSTDGVHNSE--------EEYNEFINSVRIT 202
            |.                  ||.|.  :.::.|::..|  |:.|        :.|....|| .|:
Human   297 LDPDNEGELRHTRKREAPHVKNNAI--ISLRKDLNEDD--HHHECLNVTQLLKYYGHGANS-PIS 356

  Fly   203 PRAFMKLCPALLAQIDNGVC----KQPAVRSVNLNDKN------QKIW-YAWIYASITMLILSAC 256
            ...|..||||||.|||:.:|    .:..|..:| .|||      ..|. .|||...|::.::|..
Human   357 TDLFTYLCPALLYQIDSRLCIEHFDKLLVEDIN-KDKNLVPEDEANIGASAWICGIISITVISLL 420

  Fly   257 GLLGILLVPLMKSAAYQEILKFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPLESDHK 321
            .|||::|||::....::.:|.|||::||||::||||:|||||:....:...:...|     ..|.
Human   421 SLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHG-----HGHS 480

  Fly   322 HSNEA--------ALLCGCTFLAALF-MYMLENLIPLLKGGKP---------------------- 355
            |.:|:        |:|.|...|..:: ::::|:.|.:.|..|.
Human   481 HGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKL 545

  Fly   356 ------------------------------------------------------------GHGHS 360
                                                                        .|.||
Human   546 SDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHS 610

  Fly   361 HG--------------------------HGHSHGRSHGHMEKPAAKDAIDLPPPRELNVMLQEAK 399
            .|                          |.|.....|.|..........||
Human   611 DGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDL-------------- 661

  Fly   400 LDEKTPDRPLTPVAFMVIIGDGLHNLTDGLAIGAAFASDPVTGFATAFAVLCHELPHELGDFALL 464
                 .:..:..:|:|||:|||:||.:|||||||||::....|.:|:.||.||||||||||||:|
Human   662 -----KETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVL 721

  Fly   465 LQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGIGDGMTQWIYAATAGSFLYIAFADLVPTM--S 527
            |:.|:::::|:..|::|::::::||.:|..:....:.:|.||:|.|||.|||:|..|::|.|  .
Human   722 LKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHG 786

  Fly   528 VAHNPEKAKDPKG-IIIQIFGILLGGLIMLAIALNE 562
            ...|.|....|.| .|:|..|:|.|..|||.|||.|
Human   787 DGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYE 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	119/436 (27%)
SLC39A10	NP_001120729.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..318		29/205 (14%)
		Zip	404..819	CDD:280666	119/438 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..484		3/24 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10579
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.910