DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zip71B and Slc39a6

DIOPT Version :9

Sequence 1:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001019916.1	Gene:	Slc39a6 / 291733	RGDID:	1304664	Length:	741	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	191/728 - (26%)
Similarity:	298/728 - (40%)	Gaps:	228/728 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSHTIDQHRPQGYSNEMPHATNV 88
            |.|....::.|:|.:||...:::.||...|:.::.:.:|:....|    |..:.:|:...|:.:.
  Rat    50 AVTMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKIKRVHIH----HDHERHSDHERHSDHE 110

  Fly    89 TYYF-------------------------EPTRVNATDEEALELQISPRGNHSNSQSEAEV---- 124
            .:..                         .|...........| .::.|.|...|.|.:||
  Rat   111 RHSHRGHAAAGKNSRKAFCPDLDSDNSGKNPNTSQGKGSRPAE-HVNGRRNGKESASSSEVTSAV 174

  Fly   125 -------PEFLE-IHDPK-HRHPRESSEPVAACLSPKS---LLSLIVNH--NDL----HKNIAYR 171
                   ..||| |..|| .|..::.:......::.||   .||.:...  ||.    .|:..|.
  Rat   175 YNTVSEGTHFLETIETPKPGRRTKDINPSTPPSITEKSRVGRLSRLARRKGNDSVSEPRKSFMYS 239

  Fly   172 KLLIKNDVSSTDGVHNSEEEYN--EFINSVRITPRA------FMKLCPALLAQIDNGVC--KQPA 226
            :       :|.|   |.:|.:|  :.:.|..::.:|      |..||||::.|||...|  ...:
  Rat   240 R-------TSND---NIQECFNATKLLTSHGMSVQALLNATEFNYLCPAIINQIDARSCLIHTAS 294

  Fly   227 VRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVPLMKSAAYQEILKFLVSIAVGTLAGDA 291
            .:...:..|...:..||:...|.:.|:|...|||::|||||....::.:|.|||::|||||:|||
  Rat   295 EKKAEIPPKTYSLQIAWLGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDA 359

  Fly   292 LMHLLPH---ALFKEEKHEEEVTGI--NPLESDHKHSN--EAALL----CGCTFLAAL-FMYMLE 344
            |:|||||   :......|||....:  .||.|.....|  |::..    .|.|.|..| ||:::|
  Rat   360 LLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSAQNLEESSYFDSTWKGLTALGGLYFMFLVE 424

  Fly   345 NLIPLLK-----------------------------------------GGKP------------- 355
            :::.|:|                                         |.:|
  Rat   425 HVLTLIKQFKDKKKKNQKKPENDEDVESKKQLSKYESQLSTNEEKVDTGERPESYLQADSQEPSP 489

  Fly   356 ----------------GHGHS-----------------------------------------HGH 363
                            .|.|.                                         |.|
  Rat   490 FDSQQPTLLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHH 554

  Fly   364 GHSHGRSHGHMEKPAAKDAIDLPPPRELNVMLQEAKLDEKTPDRPLTPVAFMVIIGDGLHNLTDG 428
            .|.:...|.|.::.:.                      |:..|..:..:|:|||:||||||.:||
  Rat   555 HHQNHHPHSHSQRYSR----------------------EELKDAGIATLAWMVIMGDGLHNFSDG 597

  Fly   429 LAIGAAFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGL 493
            |||||||.....:|.:|:.||.||||||||||||:||:.|:::::||..|.:|::|:::||:.|:
  Rat   598 LAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGI 662

  Fly   494 FIAGIGDGMTQWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKG------IIIQIFGILLGG 552
            ||....:.::.||:|.|||.|:|:|..|:||.|  .||  .|.| .|      ..:|..|||||.
  Rat   663 FIGHYAENVSMWIFALTAGLFMYVALVDMVPEM--LHN--DASD-HGCSRWGYFFLQNAGILLGF 722

  Fly   553 LIMLAIALNEHDL 565
            .|||.|::.||.:
  Rat   723 GIMLLISIFEHKI 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	134/445 (30%)
Slc39a6	NP_001019916.1	TroA-like	<77..>123	CDD:294188	6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..172		11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..213		4/23 (17%)
		Zip	309..728	CDD:280666	134/445 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..494		2/59 (3%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2586
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880