Protein Alignment Zip71B and SLC39A12

DIOPT Version :9

• Sequence 1: NP_001097608.1
• Gene: Zip71B / 39626
• FlyBaseID: FBgn0036461
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001138667.1
• Gene: SLC39A12 / 221074
• HGNCID: 20860
• Length: 691
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 158/600 - (26%)
• Similarity: 265/600 - (44%)
• Gaps: 160/600 - (26%)

  Fly     6 VLVLNL--FCLGSLFFKTVPASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSH 68
            ::.|:|  .|||.   ..:|:...:.:|   ||.......|:....|:.|:.:|
Human   212 IITLSLQGVCLGQ---GNLPSPDYFTEY---IFSSLNRTNTLRLSELDQLLNTL----------- 259

  Fly    69 TIDQHRPQGYSNEMPHATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDP 133
               ..|.....||..|      .|:..:.|.         |:...::||..|..|
Human   260 ---WTRSTCIKNEKIH------QFQRKQNNI---------ITHDQDYSNFSSSME---------- 296

  Fly   134 KHRHPRESSE-PVA---ACLSPKSLLSLIVNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNE 194
                 :||.: ||:   .|.|.:.|:.:.     |.|.::   |:.|.|
Human   297 -----KESEDGPVSWDQTCFSARQLVEIF-----LQKGLS---LISKED---------------- 332

  Fly   195 FINSVRITPRAFMKLCPALLAQIDNGVCKQPAVRSVNLNDKNQKI------WYAWIYASITMLIL 253
                       |.::.|.::.|:.:..|..|       .|:..|:      .|.:...::|:|.|
Human   333 -----------FKQMSPGIIQQLLSCSCHLP-------KDQQAKLPPTTLEKYGYSTVAVTLLTL 379

  Fly   254 SACGLLGILLVPLMKSAA--YQEILKFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPL 316
            .:  :||..|| |..|..  |:.||:..|.:|||||:||||:||:|..|   ..|::|..
Human   380 GS--MLGTALV-LFHSCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---GLHKQEAP----- 433

  Fly   317 ESDHKHSNEAALLCGCTFLAALF-MYMLENLIPLL--KGGKPGHGHSHGH-GHSH---------- 367
            |..|.|.::..:......:..:. .:::|....||  ...|.|....:|| ||||
Human   434 EFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQGLSLVNGHVGHSHHLALNSELSD 498

  Fly   368 ----GRSHG--HMEKPAAKDAIDLPPPRELNVMLQEAKLDEKTPD----RPLTPVAFMVIIGDGL 422
                |:|..  .::.|....|.::|             :...|..    :.::.:|.|:::||.|
Human   499 QAGRGKSASTIQLKSPEDSQAAEMP-------------IGSMTASNRKCKAISLLAIMILVGDSL 550

  Fly   423 HNLTDGLAIGAAFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFV 487
            ||..|||||||||:|...:|..|..|:||||:|||:||||:||.:|:||:.|:.||.:||:.:|:
Human   551 HNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFM 615

  Fly   488 GMSVGLFIAGIGDGMTQ-WIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKGIIIQIFGILLG 551
            |:.:||.::  .|...| ||:..|||.|||::..:::|.|:   :.:..:.....::|.||::||
Human   616 GLYIGLSVS--ADPCVQDWIFTVTAGMFLYLSLVEMLPEMT---HVQTQRPWMMFLLQNFGLILG 675

  Fly   552 GLIMLAIALNEHDLE 566
            .|.:|.:|:.|.:::
Human   676 WLSLLLLAIYEQNIK 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	112/343 (33%)
SLC39A12	NP_001138667.1	Zip	369..671	CDD:308248	106/330 (32%)
		XEXPHE-motif	580..585		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41105
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920