DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zip71B and Slc39a6

DIOPT Version :9

Sequence 1:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_631882.2	Gene:	Slc39a6 / 106957	MGIID:	2147279	Length:	765	Species:	Mus musculus

Alignment Length:	776	Identity:	190/776 - (24%)
Similarity:	287/776 - (36%)	Gaps:	300/776 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQ-----FDPSHTIDQHRPQGYSNEMP 83
            |.|....::.|:|.:||...:::.||...|:.::.:.:|:     .|..|..|......:.:...
Mouse    50 AVTMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKIKRVHIHHDHEHHADHEHHSDHEHHSD 114

  Fly    84 HATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDPKHRHPRESSEPVAA- 147
            |.            :.:|.|          :||:.:           |...|.|....|..||.
Mouse   115 HE------------HHSDHE----------HHSDHE-----------HHSDHEHHSHRSHTVAGK 146

  Fly   148 ------C---------LSPKSLL---SLIVNHNDLHKNIAYRKLLIKNDVSS---TDGVHNSEEE 191
                  |         .:|::.|   |....|.:..:|       ||...||   |..|:|:..|
Mouse   147 NNRKAFCPDLDSDNSGKNPRTSLGKGSRPAEHMNGRRN-------IKESASSSEVTSAVYNAVSE 204

  Fly   192 YNEFINSVRITPR---------------------------------------------------- 204
            ...|:.::. ||:
Mouse   205 GTRFVETIE-TPKPGRRTKDVNPSTPPSITEKSRVGRLSRLARKKSNESVSEPRKSFMYSRNTND 268

  Fly   205 --------------------------AFMKLCPALLAQIDNGVC--KQPAVRSVNLNDKNQKIWY 241
                                      .|..||||::.|||...|  ...:.:...:..|...:..
Mouse   269 NIQECFNTTKLLTSHGMSIQALLNATEFNYLCPAIINQIDARACLIHTASEKKAEIPPKTYSLQI 333

  Fly   242 AWIYASITMLILSACGLLGILLVPLMKSAAYQEILKFLVSIAVGTLAGDALMHLLPHALFKEE-- 304
            ||:...|.:.|:|...|||::|||||....::.:|.|||::|||||:||||:|||||:....:
Mouse   334 AWLGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDALLHLLPHSHASHQHS 398

  Fly   305 -KHEEEVTGI--NPLESDHKHSN--EAALL----CGCTFLAAL-FMYMLENLIPLLKGGK----- 354
             .|||....:  .||.|.....|  |::..    .|.|.|..| ||:::|:::.|:|..|
Mouse   399 HSHEEPAMEMKRGPLFSHLSAQNIEESSYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKK 463

  Fly   355 --------------------------------PG------------------------------- 356
                                            ||
Mouse   464 NQKKPENDEDVESKKQLSKYDSQLSSNEEKVDPGERPESYLRADSQEPSPFDSQQPTMLEEEEVM 528

  Fly   357 ----------------------HGHSHG-------------------HGHSHGRSHGHMEKPAAK 380
                                  |.|.|.                   |.|.|...|.|..
Mouse   529 IAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSH----- 588

  Fly   381 DAIDLPPPRELNVMLQEAKLDEKTPDRPLTPVAFMVIIGDGLHNLTDGLAIGAAFASDPVTGFAT 445
                           .:....|:..|..:..:|:|||:||||||.:|||||||||.....:|.:|
Mouse   589 ---------------SQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLST 638

  Fly   446 AFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGIGDGMTQWIYAAT 510
            :.||.||||||||||||:||:.|:::::||..|.:|::|:::||:.|:||....:.::.||:|.|
Mouse   639 SVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALT 703

  Fly   511 AGSFLYIAFADLVPTMSVAHNPEKAKDPKG------IIIQIFGILLGGLIMLAIALNEHDL 565
            ||.|:|:|..|:||.|  .||  .|.| .|      ..:|..|||||..|||.|::.||.:
Mouse   704 AGLFMYVALVDMVPEM--LHN--DASD-HGCSRWGYFFLQNAGILLGFGIMLLISIFEHKI 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	136/443 (31%)
Slc39a6	NP_631882.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..196		24/139 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..257		2/48 (4%)
		Zip	333..752	CDD:280666	136/443 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..519		3/60 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	219	1.000	Domainoid score	I2632
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.910