DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zip71B and slc39a12

DIOPT Version :9

Sequence 1:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_002939046.1	Gene:	slc39a12 / 100493177	XenbaseID:	XB-GENE-6051312	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	147/586 - (25%)
Similarity:	255/586 - (43%)	Gaps:	118/586 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVLNL--FCLGSLFFKTVPASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSH 68
            :|.|:|  .|:....|......|::      |||.:.....:....:..|     :|:::.....
Frog   213 ILTLSLQRVCITRKQFPNAEFFTDF------IFQSFNRTNDLYAPDIAEL-----IGELKATGDC 266

  Fly    69 TIDQHRPQGYSNEMPHATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDP 133
            :...:|.:...:.:|...|                    ::....|.......:::.| :|.|.
Frog   267 SKLSNRRKSVRSVIPQKDN--------------------ELLSNTNEEKGHDHSDIYE-VEAHS- 309

  Fly   134 KHRHPRESSEPVAACLSPKSLLSLIVNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNEFINS 198
            ::.|...|      |.|...|:                |:..||..|..     |:|:
Frog   310 RYWHQTHS------CFSVYELV----------------KVFFKNSHSPV-----SKEQ------- 340

  Fly   199 VRITPRAFMKLCPALLAQIDNGVCKQPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILL 263
                   |.::.||::.|:....|...:..:..|........|.  |::|::|:|:...:.|..|
Frog   341 -------FKQISPAIIHQLLTCSCPPASNGTTRLAPPTTLEKYG--YSTISVLLLTIGSMFGATL 396

  Fly   264 VPLMKSAA--YQEILKFLVSIAVGTLAGDALMHLLPHALFKEE--KHEEEVTGINPLESDHKHSN 324
            : :..|..  |:.||:..|.:|||||:||||:||:|..|...|  .||..:.     :.|:....
Frog   397 I-IFSSCEENYKLILQLFVGLAVGTLSGDALLHLIPQVLGVHEVVTHEHHMQ-----QGDYIFEE 455

  Fly   325 EAALLCGCTFLAALFMYMLENLIPLLKGGKPGHGHSHGHGHSHGRSHGH-----------MEKPA 378
            ...|......:..::.:.|.|.:..|....|..|.|..:||   .:|.|           ..|..
Frog   456 NEYLWKIMGMIGGIYGFFLINKLFFLLVSSPKQGLSLMNGH---LTHSHDLPLDAHLGDQSRKAK 517

  Fly   379 AKDAIDLPPPRELNVMLQEAKLDEKTPDRP--------LTPVAFMVIIGDGLHNLTDGLAIGAAF 435
            :...|.|..|.:    .:.:::.|..|.||        ::.:|.|:::||.|||..||:.||:||
Frog   518 SSSTIQLRSPDD----CEHSEVPETLPVRPKARRKSKGISLLAIMILVGDSLHNFADGMVIGSAF 578

  Fly   436 ASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGIGD 500
            :|...||.|:..|:||||:|||:||||:||.||:|.:.|..||.:|::.:|.|:.:||.::...|
Frog   579 SSSTETGIASTVAILCHEIPHEMGDFAVLLNTGLSAKIAFLMNFISALTAFAGLYIGLSLSANPD 643

  Fly   501 GMTQWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKGIIIQIFGILLGGLIMLAIALNEHDL 565
             :..||:|.|||.|||::..:::|.|.   :.:..:......:|..|:|||.|.:|.:|:.||.:
Frog   644 -VQIWIFAVTAGMFLYLSLVEMLPEMI---HVQTQRPWLMFFLQNLGLLLGWLCLLLLAIYEHKI 704

  Fly   566 E 566
            :
Frog   705 Q 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	108/339 (32%)
slc39a12	XP_002939046.1	ZIP4_domain	63..223	CDD:375719	3/9 (33%)
slc39a12	XP_002939046.1	Zip	378..680	CDD:308248	101/318 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020