DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and SLC7A7

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001119577.1	Gene:	SLC7A7 / 9056	HGNCID:	11065	Length:	511	Species:	Homo sapiens

Alignment Length:	462	Identity:	243/462 - (52%)
Similarity:	326/462 - (70%)	Gaps:	11/462 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FEVPPAEPNNSTA---DSGSQG-SGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIG 76
            :|| .::|...|:   |..|.| ..|||||:|.||:||.:|||.::||||||||||||.:|.|.|
Human     7 YEV-ASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFG 70

  Fly    77 QSLIVWVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAIT 141
            .||::|.:.|:.|:.||||||||||.|.|||..||||..|||...||:.||.:|||:.||..||.
Human    71 LSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAII 135

  Fly   142 ALTFAIYLLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVG 206
            |:|||.|:::|.:|||.||..|.:|||||.||:||.|||..|||.|.|.||||..||:||:.::.
Human   136 AITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIV 200

  Fly   207 AGVWWLFDGNTEHWDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICI 271
            ||:..|..|.:.|::|.|.|.....|.||||.||.|||||||:.||:||||:|:|.||||.:|.|
Human   201 AGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGI 265

  Fly   272 SMPVVTVIYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFA 336
            |||:||:||::||:||::||...:||:||||||||.|::.|..:||:|.:||.|.||.||.:|.|
Human   266 SMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVA 330

  Fly   337 SSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLI 401
            :|||||||:|.||||.||.:|:|...||||||:|.|::.|:.|.:||::.||||.|:....|..:
Human   331 ASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGL 395

  Fly   402 SVSGLLWMRYKQPKTERPIKVNLALPIIYLIVCLFLV---IFSCTQTPYVVGIGTIIILSGIPVY 463
            |:.|.|::|:|:|...||:|:::..||::.:..:|||   ::|.|....   ||..|.|||:|.|
Human   396 SIVGQLYLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSL---IGIAIALSGLPFY 457

  Fly   464 YLTIHKP 470
            :|.|..|
Human   458 FLIIRVP 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	241/456 (53%)
SLC7A7	NP_001119577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		6/21 (29%)
SLC7A7	NP_001119577.1	2A0308	20..493	CDD:273332	239/448 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H88701
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890