DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and HIP1

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_011707.1	Gene:	HIP1 / 853104	SGDID:	S000003423	Length:	603	Species:	Saccharomyces cerevisiae

Alignment Length:	505	Identity:	113/505 - (22%)
Similarity:	197/505 - (39%)	Gaps:	105/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SDSLIPRQVFEVPPAEPNNSTADSGSQG-------------SGVKLKKQIGLLDGVAIIVGVIVG 58
            :||..|....:.|..  |.:|.|..|..             :...|.|.:.:...:.:.||..:|
Yeast    43 TDSAFPLSSKDSPGI--NQTTNDITSSDRFRRNEDTEQEDINNTNLSKDLSVRHLLTLAVGGAIG 105

  Fly    59 SGIFVSPKGVLKFSGSIGQSLIV-WVL--SGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPL 120
            :|::|:....|...|.  .||:: ||:  :.:.:::.:|  .||....|..||...|......|.
Yeast   106 TGLYVNTGAALSTGGP--ASLVIDWVIISTCLFTVINSL--GELSAAFPVVGGFNVYSMRFIEPS 166

  Fly   121 PAFL----YL--WVALLILVPTGNAITALTFAIYLLKPFWP---SCDAPIEAVQLLAAAMICVLT 176
            .||.    ||  |:.||.|.....:||.         .:|.   :.||.:       |.....:.
Yeast   167 FAFAVNLNYLAQWLVLLPLELVAASITI---------KYWNDKINSDAWV-------AIFYATIA 215

  Fly   177 LINCYNVK------WVTRVTDIFT--GTKVVALLVIVGAGVWWLFDGNTEHWDNP-----FSGGL 228
            |.|..:||      :|..:..|.:  |..::.:::..|.|....:.|. ::|.:|     .|.|.
Yeast   216 LANMLDVKSFGETEFVLSMIKILSIIGFTILGIVLSCGGGPHGGYIGG-KYWHDPGAFVGHSSGT 279

  Fly   229 QDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFSVLSP 293
            |..| :...|.:..|||||.........|.|:|...:|||...:..::|..| :|.:.....|.|
Yeast   280 QFKG-LCSVFVTAAFSYSGIEMTAVSAAESKNPRETIPKAAKRTFWLITASY-VTILTLIGCLVP 342

  Fly   294 D------------EILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFVGAR 346
            .            :..||..|.......:.|..| :|...:..:.....|.|::|.||.....|.
Yeast   343 SNDPRLLNGSSSVDAASSPLVIAIENGGIKGLPS-LMNAIILIAVVSVANSAVYACSRCMVAMAH 406

  Fly   347 NGHLPAAISLI-------NVNCLTPVPSLIFLGVLTLLLLFIE--DVYVLINYVSYVEALFTLIS 402
            .|:||..::.:       |...||     :|.|:|:.:....:  :|:..::.:|.:..:|..::
Yeast   407 IGNLPKFLNRVDKRGRPMNAILLT-----LFFGLLSFVAASDKQAEVFTWLSALSGLSTIFCWMA 466

  Fly   403 VSGLLWMRYKQPK--TERPIKVNLALPII---------YLIVCLFLVIFS 441
            :: |..:|::|..  .||.:.   .||.|         |..:.||||:.:
Yeast   467 IN-LSHIRFRQAMKVQERSLD---ELPFISQTGVKGSWYGFIVLFLVLIA 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	109/490 (22%)
HIP1	NP_011707.1	2A0310	88..567	CDD:273334	104/458 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920