DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnd and MMP1

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_013039.1	Gene:	MMP1 / 850665	SGDID:	S000003984	Length:	583	Species:	Saccharomyces cerevisiae

Alignment Length:	577	Identity:	131/577 - (22%)
Similarity:	209/577 - (36%)	Gaps:	155/577 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARVQASDSLIPRQVFEVPPAEPNN---------STADSGSQGSGV------------------K 38
            :::||.|.|     |...|..|.||         ...||.:...|:                  .
Yeast     9 LSKVQFSTS-----VLSTPSNEGNNLIHRFKNSFKRNDSPAIQEGLLYSELSEEEKIQWDLANQP 68

  Fly    39 LKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQS--------LIVWVLSGVLSMVGALC 95
            .||.:.......|.:|..:|:|:|:          .:|:|        ||.::|.|...:....|
Yeast    69 YKKVLDQRHLTMIAIGGTLGTGLFI----------GLGESLASGPASLLIGFLLVGASMLCVVQC 123

  Fly    96 YAELGTMIPKSGGDYAYIGTAF-GPLPAF------LYLWVALLILVPTGNAITALTFAIYLLKPF 153
            .|||....|.| |.||...:.| .|...|      |.:|   ||..|:.....:||.:      :
Yeast   124 GAELSCQYPVS-GSYALHASRFIDPSVGFSIGINYLLMW---LISYPSELVGCSLTIS------Y 178

  Fly   154 W-PSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLFDG-- 215
            | ||    :.....:|.|.:..: |:|.:..:.........:..|:|||.:.:..|:..:..|
Yeast   179 WAPS----VNPAAWVAIAFVLSM-LLNLFGARGFAESEFYMSIFKIVALFIFIIIGIVLIAGGGP 238

  Fly   216 ------NTEHWDNPFSGGLQDPGYIAL--------AFYSGLFSYSGWNYLNFVTEELKDPYRNLP 266
                  .|::|        .|||..|:        .|.|..:|:||...:...:.|.:. ..::.
Yeast   239 DSTGYIGTKYW--------HDPGSFAVPVFKNLCNTFVSAAYSFSGTEMVVLTSTEARS-VSSVS 294

  Fly   267 KAI------CISMPVVTVIYMITNIAY-----FSVLSPDEILSSDAVAV-----TFGDKMLGYMS 315
            :|.      .|...:||||.:...:.|     .|..|.::|.:|..|..     ..|.::..:|:
Yeast   295 RAAKGTFWRIIIFYIVTVIIIGCLVPYNDPRLISGSSSEDITASPFVIALSNTGAMGTRVSHFMN 359

  Fly   316 WIMPFAVACSTFGSLNGAIFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLF 380
            .::..||    |...|..::|||||....|..|.||...:.::.|. .|:..:...|...||...
Yeast   360 AVILIAV----FSVCNSCVYASSRLIQGLATAGQLPKICAYMDRNG-RPLVGMAICGAFGLLGFL 419

  Fly   381 IEDVYVLINYVSYVEALFTLISVSGL-LW-------MRYKQP-KTERPIKVNLALPIIY-LIVCL 435
            :    |..|..:....||.|.|:|.. .|       :|::.. |.:...|.:    ||| ..:.:
Yeast   420 V----VSKNQGTVFTWLFALCSISFFTTWFCICFCQVRFRMAMKAQGRSKDD----IIYRSTLGI 476

  Fly   436 FLVIFSCTQTPYVVGIGTIIILSGIPVYYLTIHKPVKWLADTSQAINLWCSKFFICM 492
            :..||.|.....:| ||.|.: |..||            ...|.|.|.    |..||
Yeast   477 YGGIFGCILNVLLV-IGEIYV-SAAPV------------GSPSSAANF----FEYCM 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	125/556 (22%)
MMP1	NP_013039.1	2A0310	70..547	CDD:273334	119/511 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.880