DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and Slc7a8

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_445894.1	Gene:	Slc7a8 / 84551	RGDID:	619904	Length:	533	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	246/481 - (51%)
Similarity:	342/481 - (71%)	Gaps:	19/481 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ADSGSQGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIVWVLSGVLSMVG 92
            |::.|.|.||.|||:|||:....||||.|:||||||||||||:.:||:|.:||||:::||::.||
  Rat    26 AEASSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGVITAVG 90

  Fly    93 ALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYLLKPFWPSC 157
            ||||||||..||||||||:|:...||.|..||.||:|:|::.||..|:.||||:.|:|:|.:|:|
  Rat    91 ALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTC 155

  Fly   158 DAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGV--------WWLFD 214
            ..|...::||||..:.:||.:||.:|:|.|||.||||..|::||.:|:..||        :||..
  Rat   156 FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGVVQICKGEFFWLEP 220

  Fly   215 GNT-EHWDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTV 278
            .|. |::..|      |.|.:||||..|.|:|.|||:||:|||||.|||:|||:||.||:|:||.
  Rat   221 KNAFENFQEP------DIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTF 279

  Fly   279 IYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFV 343
            :|:..||||.:.:||.|:|:|:|||||||:|:||.|:||||.:||.||||.:||::|.||||||.
  Rat   280 VYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFA 344

  Fly   344 GARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLW 408
            |||.||||:.:::|:|...||:|:|:|..:.|||:|...|:|.|||||.::..||..::|:|.:.
  Rat   345 GAREGHLPSVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIV 409

  Fly   409 MRYKQPKTERPIKVNLALPIIYLIVCLFLVIFSCTQTPYVVGIGTIIILSGIPVYYLTI---HKP 470
            :|:|:|...||||::|..|||||:...||:|||....|.|.|||..|:|:|:|||:|.:   |||
  Rat   410 LRWKKPDIPRPIKISLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKP 474

  Fly   471 VKWLADTSQAINLWCSKFFICMPNQE 496
             |...|..:::.|...|..:.:..||
  Rat   475 -KCFNDFIESLTLVSQKMCVVVYPQE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	244/479 (51%)
Slc7a8	NP_445894.1	2A0308	1..499	CDD:273332	244/479 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..533		246/481 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1358
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.710