DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and Slc7a7

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_112631.1	Gene:	Slc7a7 / 83509	RGDID:	619902	Length:	512	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	250/502 - (49%)
Similarity:	340/502 - (67%)	Gaps:	28/502 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FEVPPAEPNNSTADSGSQGSG-------VKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSG 73
            :|| .|:.....||..:||.|       |||||:|.||:||.:|||.::||||||||||||.:|.
  Rat     7 YEV-AAQNEADEADGSAQGDGAGPAAEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSA 70

  Fly    74 SIGQSLIVWVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGN 138
            |.|.||::|.:.|:.|:.||||||||||.|.|||..||||..|||...||:.||.:|||:.||..
  Rat    71 SFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQ 135

  Fly   139 AITALTFAIYLLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLV 203
            |:.|:|||.|:::|.:|||.||..|.:|||||.||:||.|||..|||.|.|.||||..||:||:.
  Rat   136 AVIAITFANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIA 200

  Fly   204 IVGAGVWWLFDGNTEHWDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKA 268
            ::.||:..|..|.|.::::.|.|.....|.||||.||.|||||||:.||:||||:::|.||||.:
  Rat   201 VIIAGIVRLGQGATTNFEDSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLS 265

  Fly   269 ICISMPVVTVIYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGA 333
            |.||||:||:||::||:||:|||...:||:||||||||.|::.|..:|.:|.|||.|.||.||.:
  Rat   266 IGISMPIVTIIYLLTNVAYYSVLDIKDILASDAVAVTFADQIFGIFNWTIPLAVALSCFGGLNAS 330

  Fly   334 IFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALF 398
            |.|:|||.|||:|.||||.||.:|:|...||||||:|.|:|.|:.|.:||::.||||.|:....|
  Rat   331 IVAASRLLFVGSREGHLPDAICMIHVERFTPVPSLLFNGILALVYLCVEDIFQLINYYSFSYWFF 395

  Fly   399 TLISVSGLLWMRYKQPKTERPIKVNLALPIIYLIVCLFLV---IFSCTQTPYVVGIGTIIILSGI 460
            ..:|:.|.|::|:|:|...||:|::|..||::.:..:|||   ::|.|... ::|||  |.|||:
  Rat   396 VGLSIVGQLYLRWKEPDRPRPLKLSLFFPIVFCLCTIFLVAVPLYSDTINS-LIGIG--IALSGL 457

  Fly   461 PVYYLTIHKPV--------KWLADTSQAINLWCSKFFICMPNQEKFD 499
            |.|:|.|..|.        :.:|.|::.:.:      |||....:.|
  Rat   458 PFYFLIIRVPEHKRPLCLRRIVASTTRYLQI------ICMSVAAEMD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	246/491 (50%)
Slc7a7	NP_112631.1	2A0308	24..496	CDD:273332	243/480 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H88701
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860