DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and slc7a5

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001121830.1	Gene:	slc7a5 / 797250	ZFINID:	ZDB-GENE-080818-4	Length:	523	Species:	Danio rerio

Alignment Length:	484	Identity:	241/484 - (49%)
Similarity:	337/484 - (69%)	Gaps:	7/484 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EVPPAEPNNSTADSGSQGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIV 81
            ::.|..|:...:.:..:.: |.||:.|.|::|||||||.|:||||||:|.||:|.:||:|.||:|
Zfish    41 DITPGSPSTDISPADGEET-VVLKRTITLVNGVAIIVGTIIGSGIFVTPTGVVKEAGSVGLSLVV 104

  Fly    82 WVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFA 146
            |.:.||.|.:||||||||||.|.|||||||||...:|.|||||.||:.|||:.|:...|.|..||
Zfish   105 WTVCGVFSTIGALCYAELGTTITKSGGDYAYILEVYGSLPAFLKLWIELLIIRPSSQYIVAYVFA 169

  Fly   147 IYLLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWW 211
            .|:|||.:|.|..|....:|:|...|.:||.:|||:||..|||.|.|...|::||.:|:..|...
Zfish   170 TYILKPIFPVCPVPETGAKLVACLCILLLTAVNCYSVKAATRVQDAFAAAKLLALGLIIIIGFVE 234

  Fly   212 LFDGNTEHW--DNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMP 274
            :..|:|...  :|.|.|...|.|.|.||.|||||:|.|||||||||||:.:||:|||:||.||:|
Zfish   235 IGKGDTVELLPENSFKGSNTDFGNIGLALYSGLFAYGGWNYLNFVTEEMIEPYKNLPRAIIISLP 299

  Fly   275 VVTVIYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSR 339
            :|||:|::||:|||:.|||:::|||:||||.||:..||.|:||:|..|..|.|||:||::|.|||
Zfish   300 IVTVVYVLTNLAYFTTLSPEKMLSSEAVAVDFGNYHLGPMAWIIPVFVGLSCFGSVNGSLFTSSR 364

  Fly   340 LFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVS 404
            |||||:|.||||:.:|:|:.:.|||:|||||..::|||..|..|::.:||:.|:...|...:::.
Zfish   365 LFFVGSREGHLPSLLSMIHPDLLTPLPSLIFTCIMTLLYAFSNDIFSVINFFSFFNWLCIAMAIV 429

  Fly   405 GLLWMRYKQPKTERPIKVNLALPIIYLIVCLFLVIFSCTQTPYVVGIGTIIILSGIPVYYLTI-- 467
            |::|:|||:|:.|||||||:.|||::::.||||::.|..:||....||..||.:|:|||:..:
Zfish   430 GMMWLRYKKPELERPIKVNILLPIVFVLACLFLIVVSFWKTPVECAIGFGIIATGVPVYFFGVWW 494

  Fly   468 -HKPVKWLADTSQAINLWCSKFFICMPNQ 495
             .|| |||.....:..:.|.|....:|.:
Zfish   495 QTKP-KWLLQIIFSSTVMCQKMMEVVPQE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	240/479 (50%)
slc7a5	NP_001121830.1	2A0308	36..522	CDD:273332	241/482 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760