DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and slc7a4

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_919408.2	Gene:	slc7a4 / 796100	ZFINID:	ZDB-GENE-030919-2	Length:	677	Species:	Danio rerio

Alignment Length:	413	Identity:	105/413 - (25%)
Similarity:	194/413 - (46%)	Gaps:	61/413 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIV-WVLSGVLSMVGALCYAELGTM 102
            ||:.:..:|...:.||.:||||::|....|.|  .:.|.:::: ::::||.|::.||||||.|..
Zfish    33 LKRCLNTVDLALLGVGGMVGSGLYVLTGTVAK--DTAGPAVVISFLIAGVASLMAALCYAEFGAR 95

  Fly   103 IPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYLLKPF-------------- 153
            :||:|..|.:...:.|.:.|||..|..:|..: .|.|..|..::.||...|
Zfish    96 VPKTGSAYMFTYVSVGEIWAFLIGWNVILEYM-IGGAAVARAWSGYLDSIFNHRIQNFTESHVMR 159

  Fly   154 WPSCDAPIEA--VQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLFDGN 216
            |   :.|..|  ..|||||::.|.:....:.|:..:.:..||:...:|.::.|:..| :.|.|
Zfish   160 W---EVPFLAHYPDLLAAAILLVASFFISFGVRVSSWLNHIFSAISMVVIVFILVFG-FILAD-- 218

  Fly   217 TEHWDNPFSGGLQDPGYIALAFYSGL--------FSYSGWNYLNFVTEELKDPYRNLPKAICISM 273
                  |.:...::.|:..... ||:        :::.|::.:...:||..:|.|.:|.|..||:
Zfish   219 ------PVNWSAREGGFAPFGL-SGIMAGTATCFYAFVGFDVIAASSEEASNPQRAIPAATAISL 276

  Fly   274 PVVTVIY-----MITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLN-- 331
            .:....|     ::|.:..:..|.|:..| |||..      ..|| || ..|.||..:..::|
Zfish   277 GLAATAYVLVSTVLTLMVPWHTLDPNSAL-SDAFF------RRGY-SW-AGFIVAVGSICAMNTV 332

  Fly   332 --GAIFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYV 394
              ..:|:..|:.:..|.:|...:..|.:|.....||.:::..|.|..:|..|.|:..|:.::|..
Zfish   333 LLSNLFSLPRIVYAMAEDGLFFSVFSRVNPVTKVPVIAILVFGSLMAILALIFDLEALVQFLSIG 397

  Fly   395 EAL-FTLISVSGLLWMRYKQPKT 416
            ..| :|.::.| ::.:|::..|:
Zfish   398 TLLAYTFVAAS-VIVLRFQPDKS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	105/413 (25%)
slc7a4	NP_919408.2	2A0303	11..627	CDD:273330	105/413 (25%)
slc7a4	NP_919408.2	AA_permease_C	575..625	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593011
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850