DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnd and Slc7a2

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001128158.1	Gene:	Slc7a2 / 64554	RGDID:	68387	Length:	658	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	104/465 - (22%)
Similarity:	198/465 - (42%)	Gaps:	93/465 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIPRQVFEVPPAEPNNSTADSGSQGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGS 74
            ||.|::..:      :|..||       ||.:.:..:|.:|:.||..:|:|::|....|.|  ..
  Rat    14 LIRRKIVTL------DSLEDS-------KLCRCLTTMDLIALGVGSTLGAGVYVLAGEVAK--AD 63

  Fly    75 IGQSLIV-WVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLW-VALLILVPTG 137
            .|.|::| ::::.:.|::..|||||.|..:||:|..|.|.....|.|.||:..| :.|..::.|.
  Rat    64 SGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTS 128

  Fly   138 NAITALT--------------FAIYLLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTR 188
            :...|.:              |..|....:....:.|    ...|..::.:|..:..:.||....
  Rat   129 SVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYP----DFFAVCLVLLLAGLLSFGVKESAW 189

  Fly   189 VTDIFTGTKVVALLVIVGAGVWWLFDGNTEHWD------NPFSGGLQDP------------GYIA 235
            |...||...::.||.::.||   ...||..:|.      ...|...::|            |::.
  Rat   190 VNKFFTAINILVLLFVMVAG---FVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMP 251

  Fly   236 LAFYSGL-------FSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFSV--- 290
            ..|...|       :::.|::.:....||:::|.:.:|..|..|:       ::..:|||.|
  Rat   252 YGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSL-------LVCFMAYFGVSAA 309

  Fly   291 ---LSPDEILSSDA-VAVTFGDKMLGYMSW-----IMPFAVACSTFGSLNGAIFASSRLFFVGAR 346
               :.|..:|...: :.|.|     .|:.|     ::.....|:...||.|:||...|:.:..|.
  Rat   310 LTLMMPYYLLDEKSPLPVAF-----EYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAE 369

  Fly   347 NGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEAL-FTLISVSGLL--- 407
            :|.|...::.||....||:.:.:..|.:..::.|:.|:..|::.:|....: ::|::...|:
  Rat   370 DGLLFKCLAQINSKTKTPIIATLSSGAVAAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRY 434

  Fly   408 --WMRYKQPK 415
              .:.|:|||
  Rat   435 QPGLCYEQPK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	101/453 (22%)
Slc7a2	NP_001128158.1	2A0303	5..608	CDD:273330	104/465 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940