DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and slc7a6

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001017197.1	Gene:	slc7a6 / 549951	XenbaseID:	XB-GENE-963214	Length:	514	Species:	Xenopus tropicalis

Alignment Length:	455	Identity:	237/455 - (52%)
Similarity:	326/455 - (71%)	Gaps:	6/455 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PPAEPNNSTADSGSQGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIVWV 83
            |....:.||:||......::|||:|.||:||::|||.::||||||||||||.:|.|.|.|||:|.
Frog    16 PGDTSHTSTSDSKDPQDTMQLKKEISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLILWS 80

  Fly    84 LSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIY 148
            |.|:.|::||||||||||.|.|||..||||..|||...||:.||.:|||:.||..|:.|:|||.|
Frog    81 LGGIFSVIGALCYAELGTTIKKSGASYAYILEAFGDFVAFIRLWTSLLIIEPTSQAVIAITFANY 145

  Fly   149 LLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLF 213
            |::|.:|||..|..|.:|:|||.:|::|.|||..|||.|||.|:||..||:||:.|:..|:..|.
Frog   146 LVQPVFPSCYPPYMASRLIAAACVCLITFINCAYVKWGTRVQDLFTYAKVIALIAIIITGIVKLS 210

  Fly   214 DGNTEHWDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTV 278
            .|.||::::.|:|...|.|.|:|..||.|||||||:.|||||||:|:|.||||.:|.||||:||:
Frog   211 QGQTENFEDSFAGSSWDAGEISLGLYSALFSYSGWDTLNFVTEEIKNPERNLPLSIGISMPLVTI 275

  Fly   279 IYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFV 343
            ||::||:||::||..:.:::|:||||||.|.:.|..||.:|.|||.|.||.||.:|.|:||||||
Frog   276 IYILTNVAYYTVLDFNAVVASEAVAVTFADMVYGVFSWTIPVAVALSCFGGLNSSILAASRLFFV 340

  Fly   344 GARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLW 408
            |||.||||..:.||:....||||:|:|..|.||:.|.::||:.||||.|:....|..:|::|.::
Frog   341 GAREGHLPDMLCLIHQERFTPVPALLFNCVATLIYLAVKDVFQLINYYSFSYWFFVGLSIAGQIY 405

  Fly   409 MRYKQPKTERPIKVNLALPIIYLIVCLFLVI---FSCTQTPYVVGIGTIIILSGIPVYYLTIHKP 470
            :|.|:|:..||:|::|..||::.:..:||||   :|.|... ::|||  |.|||||||::.|:.|
Frog   406 LRIKKPELPRPVKLSLFYPIVFCLCTVFLVIVPLYSDTVNS-LIGIG--IALSGIPVYFMGIYLP 467

Fly 471 470
Frog 468 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	236/452 (52%)
slc7a6	NP_001017197.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		5/14 (36%)
slc7a6	NP_001017197.1	2A0308	29..496	CDD:273332	232/442 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	1	1.000	-	-		mtm9441
Panther	1	1.100	-	-	LDO	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060