DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and Slc7a5

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_059049.1	Gene:	Slc7a5 / 50719	RGDID:	620639	Length:	512	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	245/477 - (51%)
Similarity:	333/477 - (69%)	Gaps:	20/477 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIVWVLSGVLSMVGALCYA 97
            :|.||.|::.|.|::|||||||.|:||||||:|.||||.:||.|.||:||.:.||.|:|||||||
  Rat    41 EGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYA 105

  Fly    98 ELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYLLKPFWPSCDAPIE 162
            ||||.|.||||||||:...:|.|||||.||:.|||:.|:...|.||.||.|||||.:|:|..|.|
  Rat   106 ELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEE 170

  Fly   163 AVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVI-----------VGAGVWWLFDGN 216
            |.:|:|...:.:||.:|||:||..|||.|.|...|::||.:|           :|.|     |.:
  Rat   171 AAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQG-----DAS 230

  Fly   217 TEHWDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYM 281
            ..|....|.|...|.|.|.||.|||||:|.|||||||||||:.:||||||.||.||:|:||::|:
  Rat   231 NLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYV 295

  Fly   282 ITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFVGAR 346
            :||:|||:.||.:::|:|:||||.||:..||.||||:|..|..|.|||:||::|.||||||||:|
  Rat   296 LTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSR 360

  Fly   347 NGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLWMRY 411
            .||||:.:|:|:...|||||||:|..|:||:..|..|::.:||:.|:...|...:::.|::|:|:
  Rat   361 EGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRF 425

  Fly   412 KQPKTERPIKVNLALPIIYLIVCLFLVIFSCTQTPYVVGIGTIIILSGIPVYYLTI---HKPVKW 473
            |:|:.|||||||||||:.:::.||||:..|..:||...|||..|||||:|||:..:   :|| ||
  Rat   426 KKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKP-KW 489

  Fly   474 LADTSQAINLWCSKFFICMPNQ 495
            :.....::.:.|.|....:|.:
  Rat   490 ILQVIFSVTVLCQKLMQVVPQE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	245/477 (51%)
Slc7a5	NP_059049.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		0/1 (0%)
Slc7a5	NP_059049.1	2A0308	23..511	CDD:273332	245/475 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351199
Domainoid	1	1.000	451	1.000	Domainoid score	I491
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1358
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.710