DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and slc7a3a

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001007330.2	Gene:	slc7a3a / 492363	ZFINID:	ZDB-GENE-041114-206	Length:	644	Species:	Danio rerio

Alignment Length:	450	Identity:	109/450 - (24%)
Similarity:	199/450 - (44%)	Gaps:	85/450 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQS------LIVWVLSGVLSMVG 92
            |...:..:.:..||.||:.||..:|:|::|       .:|.:.:.      ::.::::.:.||:.
Zfish    22 GEETRFARCLSTLDLVALGVGSTLGAGVYV-------LAGEVAREKAGPAIVLCFLVAALSSMLA 79

  Fly    93 ALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYL-------L 150
            .|||||.|..:||:|..|.|.....|.:.||:..|..:|..| .|.|..|..::...       :
Zfish    80 GLCYAEFGARVPKTGSAYLYSYVTVGEIWAFITGWNLILSYV-IGTASVARAWSSTFDNLIEQKI 143

  Fly   151 KPFWPSCDAP-------IEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAG 208
            ..|:.:..|.       .|...|.|..:|.:||.:..:.|.....|..||||..::.|..|:.:|
Zfish   144 SNFFRASMAMKVPGKVLAEYPDLFALILILLLTGLLAFGVSESALVNKIFTGINLIVLGFIIISG 208

  Fly   209 VWWLFDGNTEHWDNPFSGGLQD-----PGYIALAFYSG-----------------LFSYSGWNYL 251
               ...|||.:|:..:...:.|     |..|...|.||                 .:::.|::.:
Zfish   209 ---FVKGNTANWNLTYEYFINDTNITEPERIESTFGSGGFAPFGLGGILSGAATCFYAFVGFDCI 270

  Fly   252 NFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFSV------LSPDEILSSDAVAVTFGDKM 310
            ...:||.|:|.|::|..|..|:       :|...|||.|      :.|...|::.:..    .:.
Zfish   271 ATTSEEAKNPMRSIPVGIVASL-------LICFFAYFGVSAALTLMMPYYKLNTQSPL----PEA 324

  Fly   311 LGYMSW-----IMPFAVACSTFGSLNGAIFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIF 370
            ..|:.|     |:.....|:...||.|::|...|:.:..|.:|.|..::|.:|....||:.:.|.
Zfish   325 FSYVGWAPARYIVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRSLSRMNKRTKTPLLATIA 389

  Fly   371 LGVLTLLLLFIEDVYVLINYVSYVEAL-FTLISVSGLLWMRYKQP-------KTERPIKV 422
            .|::..|:.|:.|:..|::.:|....| ::|::|..|: :|| ||       :||:.:::
Zfish   390 SGIVAALMAFLFDLAALVDLMSIGTLLAYSLVAVCVLI-LRY-QPGNLSSSSQTEKLVEL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	109/449 (24%)
slc7a3a	NP_001007330.2	2A0303	4..611	CDD:273330	109/449 (24%)
slc7a3a	NP_001007330.2	AA_permease_C	559..609	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940