DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and Slc7a11

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_038958186.1	Gene:	Slc7a11 / 310392	RGDID:	1309275	Length:	505	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	211/458 - (46%)
Similarity:	310/458 - (67%)	Gaps:	3/458 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIVWVLSGVLSMVGALCYAELGT 101
            |.|||:|.||.||:||:|.::|||||:||||:|:.:||:|.||:.|...||||:.|||.||||||
  Rat    38 VVLKKKITLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGT 102

  Fly   102 MIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYLLKPFWPSCDAPIEAVQL 166
            .|.||||.|.||...||||.||:.:||.||::.|...|:.:|.|..|:|:||:..|:.|..|::|
  Rat   103 SIKKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAVISLAFGRYILEPFFIQCEIPELAIKL 167

  Fly   167 LAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLFDGNTEHWDNPFSGGLQDP 231
            :.|..|.|:.::|..:|.|..|:....|..|:.|:|:|:..||..|..|.|.|:.:.|||...:.
  Rat   168 VTAVGITVVMVLNSTSVSWSARIQIFLTFCKLTAILIIIVPGVIQLIKGQTHHFKDAFSGRDTNL 232

  Fly   232 GYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFSVLSPDEI 296
            ..:.||||.|:::|:||.||||:|||:.:|.:.:|.||||||.::||.|::||:|||:.:|.:|:
  Rat   233 MGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAICISMAIITVGYVLTNVAYFTTISAEEL 297

  Fly   297 LSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFVGARNGHLPAAISLINVNC 361
            |.|.||||||.:::||..|..:|..||.|.|||:||.:||.||||:|.:|.||||..:|:|:|:.
  Rat   298 LQSSAVAVTFSERLLGKFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVHK 362

  Fly   362 LTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLWMRYKQPKTERPIKVNLAL 426
            .||:|::|.|..||:::||..|:|.|:|::|:...||..::|:||:::|||:|...||.||.|.:
  Rat   363 HTPLPAVIVLHPLTMIMLFSGDLYSLLNFLSFARWLFMGLAVAGLIYLRYKRPDMHRPFKVPLFI 427

  Fly   427 PIIYLIVCLFLVIFSCTQTPYVVGIGTIIILSGIPVYYLTI--HKPVKWLADTS-QAINLWCSKF 488
            |.::...|||:|:.|....|:..|:|.:|.|:|:|.|||.|  .|..||....| ..::......
  Rat   428 PALFSFTCLFMVVLSLYSDPFSTGVGFLITLTGVPAYYLFIVWDKKPKWFRRLSVNNLHFSLKST 492

  Fly   489 FIC 491
            |:|
  Rat   493 FLC 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	211/458 (46%)
Slc7a11	XP_038958186.1	2A0308	1..482	CDD:273332	208/443 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760