DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnd and per1

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_594316.1	Gene:	per1 / 2541596	PomBaseID:	SPAP7G5.06	Length:	583	Species:	Schizosaccharomyces pombe

Alignment Length:	609	Identity:	117/609 - (19%)
Similarity:	187/609 - (30%)	Gaps:	231/609 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QASDSLIPRQVFEVPPAE----PNN-STADSGS------------------QGSGVKLKKQIGLL 46
            |:.|.   :.||::.|.|    |.. ..||:.|                  :..||.||:.:...
pombe    26 QSKDD---KNVFDIHPTESEVIPGEVEYADTPSHQNFLQKFFSDFKPVKADREDGVALKRHLKGR 87

  Fly    47 DGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIVWVLSGVLSMVGALCYAELGTMIPKSGGDYA 111
            ....|.:|..:|:|:||. .|.....|.....:|.:.|.|::.........||....|.:||.|.
pombe    88 HMQMIAIGGAIGTGLFVG-SGSSLADGGPASVIIDYTLIGIMMFFTVYALGELAVSYPVAGGFYN 151

  Fly   112 YIGTAFGPLPAFLYLW---VALLILVPTGNAITALTFAIYLLKPFWP---SCDAPIEAVQLLAAA 170
            |......|...|...|   :...:..|......|:||.      :|.   ||    ..:.:....
pombe   152 YAVRFIDPAWGFAVGWNYFMNYFVTFPLELTTCAITFR------YWTDINSC----AWITIFLVF 206

  Fly   171 MICVLTLINCYNVKWVTRVTDIFTGTKVVA------LLVIVGAGVWWLFDGNTEHWDNPFSGGLQ 229
            :||    ||.:.|:....|..|.:..||||      |.:|:..|                 |...
pombe   207 VIC----INLFGVRGYGEVEFILSTLKVVATTGFIILAIIINCG-----------------GVPT 250

  Fly   230 DP-GYI-----------------ALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVV 276
            || |||                 ...|.:..||:||...:.....|.:||.::||:|.......:
pombe   251 DPRGYIGGKIIKNKPFRHSFKGFCSVFTTAGFSFSGTEVVGLAAAEAEDPQKSLPRATKQVFWRI 315

  Fly   277 TVIYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMS--WIMPFAVA---------------- 323
            .:.|:::.|....::|||:            .:::|..|  ...||.:|
pombe   316 AIFYVVSLILIGLLVSPDD------------PRLMGNSSDGSTSPFVLAIKEANIRGLPSVFNAV 368

  Fly   324 --CSTFGSLNGAIFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYV 386
              .||....|...|.:||.....|..|..|
pombe   369 IIISTVSVANSCTFTASRTLHAMAAKGDAP----------------------------------- 398

  Fly   387 LINYVSYVEALFTLISVSGLLWMRYKQPKTERPIKVNLALPIIYLIVCLFLVIFSCTQTPYVVGI 451
              .:.:|                      |:|     |..|::.:.|||....|:     |:...
pombe   399 --RFFAY----------------------TDR-----LGRPLLAMAVCLLFGFFA-----YINAA 429

  Fly   452 GTI--------IILSGIP-------------VYYLTIHKPVK-------------WLADTSQAIN 482
            |.:        :.:|||.             |:.|.:.|..:             |.:....|.|
pombe   430 GDVSDTVFDWLLAISGISNFFSWGSINLCHIVFRLAMKKQGRSLDQLGFVSPMGIWGSAIGLAFN 494

  Fly   483 LWC--SKFFICM------PNQEKF 498
            :.|  ::|::.:      ||...|
pombe   495 ILCLMAEFYVSLFPIGSKPNANDF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	111/588 (19%)
per1	NP_594316.1	LysP	35..582	CDD:223903	113/597 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950