DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnd and Slc7a4

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001346821.1	Gene:	Slc7a4 / 224022	MGIID:	2146512	Length:	700	Species:	Mus musculus

Alignment Length:	463	Identity:	110/463 - (23%)
Similarity:	207/463 - (44%)	Gaps:	71/463 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARVQASDSLIPR---QVFEVPPAEPNNSTADSGSQGSGVKLKKQIGLLDGVAIIVGVIVGSGIF 62
            |||...|.:.:.|   ::..:.|.|      :|..:.|   |::.:..||...:.||.:||||::
Mouse    66 MARGLPSTACLARFCQKLNRLKPLE------ESSMETS---LRRCLSTLDLTLLGVGGMVGSGLY 121

  Fly    63 VSPKGVLKFSGSIGQS------LIVWVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLP 121
            |       .:|::.:.      |:.::::.|.|::.||||||.|..:|::|..|.:...:.|.:.
Mouse   122 V-------LTGTVAKDMAGPAVLLSFLVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGEIW 179

  Fly   122 AFLYLWVALLILVPTGNAITALTFAIYL-------LKPFWPS----CDAPIEA--VQLLAAAMIC 173
            |||..|..||..: .|.|..|..::.||       ::.|..|    ...|..|  ...|||.::.
Mouse   180 AFLIGWNVLLEYL-IGGAAVARAWSGYLDAIFNHSIRNFTESHLGVWQVPFLAHYPDFLAAGILL 243

  Fly   174 VLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLFDGNTEHWDNPFSGGLQDPGYIALAF 238
            |.:.......:..:.:...|:...::.:|.|:..|....         .|.:...::.|:....|
Mouse   244 VASAFVSCGARVSSWLNHTFSAISLIVILFIIVLGFILA---------RPHNWSAEEGGFAPFGF 299

  Fly   239 YSGL--------FSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFSVLSPDE 295
             ||:        :::.|::.:...:||.|:|...:|.||.||:.:....|::.: ...:::.|..
Mouse   300 -SGILAGTATCFYAFVGFDVIAASSEEAKNPRWAVPMAIAISLSLAAGAYILVS-TVLTLMVPWH 362

  Fly   296 ILSSD-AVAVTFGDKMLGYMSWIMPFAVACSTFGSLN----GAIFASSRLFFVGARNGHLPAAIS 355
            .|..| |:|..|..:  || || ..|.||..:..::|    ..:|:..|:.:..|.:|......:
Mouse   363 SLDPDSALADAFYRR--GY-SW-AGFIVAVGSICAMNTVLLSNLFSLPRIVYAMAADGLFFQVFA 423

  Fly   356 LINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEAL-FTLISVSGLLWMRYKQPKTERP 419
            .::.....||..::..|||..||..:.|:..|:.::|....| :|.::.| ::.:|::  |...|
Mouse   424 RVHPRTQVPVVGILVFGVLMALLALLLDLEALVQFLSIGTLLAYTFVATS-IIVLRFQ--KASPP 485

  Fly   420 IKVNLALP 427
            ....||.|
Mouse   486 SSPCLASP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	104/439 (24%)
Slc7a4	NP_001346821.1	AA_permease_2	79..657	CDD:330980	105/450 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850