DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and SLC7A13

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_620172.2	Gene:	SLC7A13 / 157724	HGNCID:	23092	Length:	470	Species:	Homo sapiens

Alignment Length:	478	Identity:	167/478 - (34%)
Similarity:	267/478 - (55%)	Gaps:	30/478 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFS-GSIGQSLIVWVLSGVLSMVGALCY 96
            :|..::||:..|...|.:.::..|:|:||||||||||.:| .::|.||.||....:|:|...||.
Human     3 RGEKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCS 67

  Fly    97 AELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAIT---ALTFAIYLLKPFWPSCD 158
            ||:....|.||..|.::...||...|||.||.:|.:    |:.:.   ||..|.|.::||:|||.
Human    68 AEISISFPCSGAQYYFLKRYFGSTVAFLNLWTSLFL----GSGVVAGQALLLAEYSIQPFFPSCS 128

  Fly   159 APIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLFDG---NTEHW 220
            .|....:.||.||:.::.::....||.||.:....:..||..|..|...||.:|..|   |.|.:
Human   129 VPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVERF 193

  Fly   221 DNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNI 285
            .|.|...|.|..::..|.:.|.|:|||......:..|||.|...:||.|..::|:|||:|::.||
Human   194 QNAFDAELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVNI 258

  Fly   286 AYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFVGARNGHL 350
            :|.:||:|.|||||||||:|:.|:....::||||||::.|.|.:|..:||.|||..::.::.|.|
Human   259 SYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQL 323

  Fly   351 PAAISLINVNC--LTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLWMRYKQ 413
            |...:.:|.:.  .|.|..|:.||.|.::|..:.|   ||||:.:..:|::::.:.|:|..||::
Human   324 PLLFNTLNSHSSPFTAVLLLVTLGSLAIILTSLID---LINYIFFTGSLWSILLMIGILRRRYQE 385

  Fly   414 PKTERPIKVNLALPIIYLIVCLFLVIFSCTQTP-----YVVGIGTIIILSGIPVYYLTIHKPVK- 472
            |....|.||.|:.|:..:::.:.||:....::|     ||:    :::|||:..|...||..::
Human   386 PNLSIPYKVFLSFPLATIVIDVGLVVIPLVKSPNVHYVYVL----LLVLSGLLFYIPLIHFKIRL 446

  Fly   473 -WLADTSQAINLWCSKFFICMPN 494
             |....:..:.|   .|.||:|:
Human   447 AWFEKMTCYLQL---LFNICLPD 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	167/478 (35%)
SLC7A13	NP_620172.2	AA_permease_2	16..398	CDD:290254	145/388 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750