DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and Slc7a12

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_543128.1	Gene:	Slc7a12 / 140918	MGIID:	2156159	Length:	465	Species:	Mus musculus

Alignment Length:	470	Identity:	135/470 - (28%)
Similarity:	239/470 - (50%)	Gaps:	21/470 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSG-SIGQSLIVWVLSGVLSMVGALCYAELG 100
            ::|.:.:|:.....|:....:|:||||:||.|||:|. :|..||.:|...|:||::.|||.||:.
Mouse     1 MQLLRALGVFHVSMILFSATLGTGIFVTPKAVLKYSSLNIPVSLSIWAGCGLLSIMSALCNAEIA 65

  Fly   101 TMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYLLKPFWPSCDAPIEAVQ 165
            |..|.||..|.::....|...|||.||:.|.... .|.....|..|..:::.|:..|.||....:
Mouse    66 TTYPLSGASYYFLKRTLGSSVAFLSLWIKLFAHF-LGIGAQCLLIATSVIQCFYSGCPAPELPTK 129

  Fly   166 LLAAAMICVLTLINCYNVK---WVTRVTDIFTGTKVVALLVIVGAGVWWLFDG---NTEHWDNPF 224
            .||.|::....:::...:|   |...|:....    :::|.::...| .|.:|   |...::|..
Mouse   130 CLALAILWSFGIVSARGIKTVAWFNTVSSFIK----LSVLCLISLTV-LLVNGKKENVSRFENAL 189

  Fly   225 SGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFS 289
            ...|.:...||.|.....:||.|.:.|..:..|:|.|...:||.:...:.:|||:|::|||:|.:
Mouse   190 DAELPNASQIADAILQVSYSYLGSSVLIVIAGEIKRPTETIPKTLIYGISIVTVLYLLTNISYLA 254

  Fly   290 VLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFVGARNGHLPAAI 354
            ||:..||:.||:|.||:.:::...:.||..|.::....||::..|.::||:|:..::.|..|:..
Mouse   255 VLTSQEIIFSDSVGVTWMNRVFPSIQWISSFLISAFLLGSVSCGIVSASRVFYSASQEGEFPSIY 319

  Fly   355 SLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLWMRYKQPKTERP 419
            |::| :..:|..:.|.:.:|:.:.:....:..|:.|||.......|:.:.|||.:||:.|...||
Mouse   320 SMLN-DHHSPAVADIQIVILSSVAIISSSIIYLVKYVSLGSFCINLLQMIGLLKIRYQNPDIPRP 383

  Fly   420 IKVNLALPIIY--LIVCLFLVIFSCTQTPYVVGIGTIIIL-SGIPVYYLTIHKPVKWLADTSQAI 481
            .||  .||.|:  :.:.|||:.....|:|.:..:..::.| .|...|:|..:  :...|.....|
Mouse   384 YKV--WLPFIFGSIALSLFLIFTPVIQSPSIEHVYQVVFLFCGFLCYWLQAN--LNGHATCFDTI 444

  Fly   482 NLWCSKFFICMPNQE 496
            ..:|...|...|:::
Mouse   445 TCYCQLLFNISPSED 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	135/468 (29%)
Slc7a12	NP_543128.1	AA_permease_2	7..412	CDD:290254	125/413 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750