DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and Slc7a10

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_446178.2	Gene:	Slc7a10 / 114518	RGDID:	621672	Length:	530	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	233/496 - (46%)
Similarity:	334/496 - (67%)	Gaps:	28/496 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PPAEPNNSTADSGSQGSG--------VKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSI 75
            |....|.|.|.|.|.|.|        |.|||:|||:....||:|.|:|||||:||||||:.|||:
  Rat    14 PGGRGNPSPAPSPSPGPGPGPGASERVALKKEIGLVSACTIIIGNIIGSGIFISPKGVLEHSGSV 78

  Fly    76 GQSLIVWVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAI 140
            |.:|.||||.|.::.:|:|||||||..||||||||||:...||.|..||.||.|:||:.||..|:
  Rat    79 GLALFVWVLGGGVTALGSLCYAELGVTIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAV 143

  Fly   141 TALTFAIYLLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIV 205
            .::||:.|:|:|.:|:|..|..|.::|:.|.:.:||.:|..:|:|.||:..||||.|::||.:|:
  Rat   144 ISMTFSNYVLQPVFPNCIPPATASRVLSMACLMLLTWVNSSSVRWATRIQVIFTGGKLLALSLII 208

  Fly   206 GAGVWWLFDGNTEH---------WDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKDP 261
            ..|...:|.|:.|.         |..|      ..|::||||..|.|::||||:||:|||||.||
  Rat   209 TVGFVQIFQGHFEELRPTNAFTFWMTP------SVGHLALAFLQGSFAFSGWNFLNYVTEELVDP 267

  Fly   262 YRNLPKAICISMPVVTVIYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACST 326
            .:|||:||.||:|:||.:|..||:|||:.:||.|:|||:|||||||:|:|||.||:||.:||.||
  Rat   268 RKNLPRAIFISIPLVTFVYTFTNVAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALST 332

  Fly   327 FGSLNGAIFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINYV 391
            ||.:||.:|.||||.|.|||.||||:.:::|:|...||:|:|:.....|.:::.:.|.|.|||||
  Rat   333 FGGINGYLFTSSRLCFSGAREGHLPSFLAMIHVRRCTPIPALLVCCGATAVIMLVGDTYTLINYV 397

  Fly   392 SYVEALFTLISVSGLLWMRYKQPKTERPIKVNLALPIIYLIVCLFLVIFSCTQTPYVVGIGTIII 456
            |::..|...:::.|||.:|:::|...|||||||.:|::||:...||::||....|.|.|:|.|||
  Rat   398 SFINYLCYGVTILGLLVLRWRRPALHRPIKVNLLIPVVYLVFWAFLLVFSFISEPMVCGVGIIII 462

  Fly   457 LSGIPVYYLTI---HKPVKWLADTSQAINLWCSKF-FICMP 493
            |:|:|:::|.:   .|| |.:...::::..|..:. |:..|
  Rat   463 LTGVPIFFLGVFWRSKP-KCVHRFTESMTRWGQELCFVVYP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	232/493 (47%)
Slc7a10	NP_446178.2	2A0308	38..503	CDD:273332	225/472 (48%)
Slc7a10	NP_446178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650