DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and SLC7A9

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001119807.1	Gene:	SLC7A9 / 11136	HGNCID:	11067	Length:	487	Species:	Homo sapiens

Alignment Length:	463	Identity:	199/463 - (42%)
Similarity:	303/463 - (65%)	Gaps:	9/463 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSGSIGQSLIVWVLSGVLSMVGALCYAELGTMI 103
            |:|::||:.|::||||.|:|||||||||.||..:.::|..||:|...|||:.:||||:|||||||
Human    26 LQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFAELGTMI 90

  Fly   104 PKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGNAITALTFAIYLLKPFWPSCDAPIEAVQLLA 168
            .||||:|.|:..|:||:||:|:.|.:|:::.||..||..|:|:.|:..||:..|..|...|:.||
Human    91 TKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLA 155

  Fly   169 AAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLVIVGAGVWWLFDGNTEHWDNPFSGGLQDPGY 233
            ||.|..::.:|..:|:..:.|.:|||..|:|.:.:|:.:|:..|..|||:::||.|.|.....|.
Human   156 AAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGA 220

  Fly   234 IALAFYSGLFSYSGWNYLNFVTEELKDPYRNLPKAICISMPVVTVIYMITNIAYFSVLSPDEILS 298
            |:||||:||::|.|||.||::||||::||||||.||.|.:|:||..|::.|::||:|::..|:|.
Human   221 ISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQ 285

  Fly   299 SDAVAVTFGDKMLGYMSWIMPFAVACSTFGSLNGAIFASSRLFFVGARNGHLPAAISLINVNCLT 363
            |.||||||||::|...|||:|..||.||.|:.||..|.:.||.:|..|.||:...:|.|:|..||
Human   286 SQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLT 350

  Fly   364 PVPSLIFLGVLTLLLLFIEDVYVLINYVSYVEALFTLISVSGLLWMRYKQPKTERPIKVNLALPI 428
            |.|::||.|::..:.:...|:..|:||.|:...||..:::.||:.||:.:.:.||||||.:.:|:
Human   351 PAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPV 415

  Fly   429 IYLIVCLFLVIFSCTQTP-----YVVGIGTIIILSGIPVYYLTIHKPVKWLADTSQAINLWCSKF 488
            :..::.:|||:......|     |.|    :.||||:..|:|.:|....|....|:.|.:.....
Human   416 LMTLISVFLVLAPIISKPTWEYLYCV----LFILSGLLFYFLFVHYKFGWAQKISKPITMHLQML 476

  Fly   489 FICMPNQE 496
            ...:|.:|
Human   477 MEVVPPEE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	198/461 (43%)
SLC7A9	NP_001119807.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
SLC7A9	NP_001119807.1	2A0308	26..484	CDD:273332	198/461 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690