DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnd and slc7a8a

DIOPT Version :9

Sequence 1:	NP_524074.1	Gene:	mnd / 39625	FlyBaseID:	FBgn0002778	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001258826.1	Gene:	slc7a8a / 100007704	ZFINID:	ZDB-GENE-121120-2	Length:	531	Species:	Danio rerio

Alignment Length:	490	Identity:	244/490 - (49%)
Similarity:	337/490 - (68%)	Gaps:	27/490 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQVFEVPP--AEPNNSTADSG-SQGSGVKLKKQIGLLDGVAIIVGVIVGSGIFVSPKGVLKFSG 73
            |||.....|  |..:...||:| :.|..|.|||:|||:....||||.|:||||||||||||:.:.
Zfish     5 PRQRGSAAPSTASEDGGAADTGNTAGQSVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAS 69

  Fly    74 SIGQSLIVWVLSGVLSMVGALCYAELGTMIPKSGGDYAYIGTAFGPLPAFLYLWVALLILVPTGN 138
            |:|.:||||:|:|:::.:|||||||||..||||||||:|:...||.|..||.||:|:|::.||..
Zfish    70 SVGLALIVWILTGIITAIGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQ 134

  Fly   139 AITALTFAIYLLKPFWPSCDAPIEAVQLLAAAMICVLTLINCYNVKWVTRVTDIFTGTKVVALLV 203
            |:.||||:.|:|:|.:|:|..|...:::|||..:.:||.:||.:|:|.|||.|:||..|::||::
Zfish   135 AVIALTFSNYVLQPLFPTCFPPENGLRILAAICLLLLTWVNCSSVRWATRVQDVFTAGKLLALIL 199

  Fly   204 IVGAGV--------WWLFDGNTEHWDNPFSGGLQDPGYIALAFYSGLFSYSGWNYLNFVTEELKD 260
            |:..|:        :||...|.   ..||..  .|.|.|||||..|.|:|.|||:||:|||||.|
Zfish   200 IIIMGIVQICKGEYYWLEPANA---FEPFQD--YDVGLIALAFLQGSFAYGGWNFLNYVTEELVD 259

  Fly   261 PYRNLPKAICISMPVVTVIYMITNIAYFSVLSPDEILSSDAVAVTFGDKMLGYMSWIMPFAVACS 325
            ||.|||:||.||:|:||.:|:..||||.:.:||.|:|:|:|||||||:|:||.||||||.:||.|
Zfish   260 PYVNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMSWIMPISVALS 324

  Fly   326 TFGSLNGAIFASSRLFFVGARNGHLPAAISLINVNCLTPVPSLIFLGVLTLLLLFIEDVYVLINY 390
            |||.:||::|.||||||.|||.||||:.:::|:|...||:|:|:|..:.|||:|...|:|.||||
Zfish   325 TFGGVNGSLFTSSRLFFAGAREGHLPSLLAMIHVKRCTPIPALLFTCISTLLMLCTSDMYTLINY 389

  Fly   391 VSYVEALFTLISVSGLLWMRYKQPKTERPIKVNLALPIIYLIVCLFLVIFSCTQTPYVVGIGTII 455
            |.::..||..::|:|.:.:|.|||...||||::|..|:|||:...||:|||....|.|.|||..|
Zfish   390 VGFINYLFYGVTVAGQIVLRIKQPDMHRPIKISLVWPVIYLLFWAFLLIFSLYSEPVVCGIGLAI 454

  Fly   456 ILSGIPVYYLTIH---KPVKWLADTSQAINLWCSK 487
            :|:|:|||:|.::   ||        |..|.:..|
Zfish   455 MLTGVPVYFLGVYWDNKP--------QCFNTFVDK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnd	NP_524074.1	2A0308	22..496	CDD:273332	239/478 (50%)
slc7a8a	NP_001258826.1	2A0308	1..497	CDD:273332	244/490 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1598
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.740