DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and SQT1

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_012277.1	Gene:	SQT1 / 854829	SGDID:	S000001451	Length:	431	Species:	Saccharomyces cerevisiae

Alignment Length:	473	Identity:	105/473 - (22%)
Similarity:	201/473 - (42%)	Gaps:	97/473 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DDGDDELQEIIELEEQ-PLD---EDDDDLEEVTLEQLEARLAMAGGDDDEEEDEEELRDRERIAA 73
            ::.:.|:...:|:|:. |:|   |:|||.|.:              :||||..|.::
Yeast    11 EEVEQEIVPTVEVEQDVPVDIEGENDDDDEMM--------------NDDEEALEVDM-------- 53

  Fly    74 ITDEATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLY--EITEHKDTVTETHF 136
             ::.:...|.|||..|||...|||.....||..|:.|.:|.:.:....:  .:|.:.::|....|
Yeast    54 -SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117

  Fly   137 SHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWH-RAAHILLAGSDSGEVF 200
            :.:|.:|.|.|::|.:.|....:...:..:.:::.|  :.::.||..| ..|.....|:..|.|:
Yeast   118 TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE--VEEIVWLKTHPTIARTFAFGATDGSVW 180

  Fly   201 VFRIPSGEC---KILPG--QSSRCESGELSGDGK-----KLFTAYVNGSVKLWDLKSCQVLIDVN 255
            .::|...:.   :::.|  ....|..||.....|     :|.|..::.::..|:..:.|.|..:.
Yeast   181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKIT 245

  Fly   256 ESHPMGFGEITHAVVACERESPFYVCAEA--------SGECSSGKGIRYNTSFHNKTIRKMLFCT 312
            ::...|.            |:|:...:.|        ||..:.|.         |..:..::.|.
Yeast   246 QAEIKGL------------EAPWISLSLAPETLTKGNSGVVACGS---------NNGLLAVINCN 289

  Fly   313 NNGPV---STI--------QSEHGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICEN 366
            |.|.:   ||:        :.:..||.:::   |:...|.|.|.:.|.|.::|  .||.| :...
Yeast   290 NGGAILHLSTVIELKPEQDELDASIESISW---SSKFSLMAIGLVCGEILLYD--TSAWR-VRHK 348

  Fly   367 PVPNDAVIRIKWLNDHTILAATSQGNLNAFDARTGILKFTLTGHYYHIYEFVY--------KPQE 423
            .|..|:|.::.:.|| .:.|:...|.:..|:||||..||...||...:.:|:.        ..|:
Yeast   349 FVLEDSVTKLMFDND-DLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQK 412

  Fly   424 NLLLTVSEDNTAKIFKVP 441
            ..::|..::..:.:|:||
Yeast   413 RKVITAGDEGVSLVFEVP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	87/399 (22%)
		WD40	<81..441	CDD:225201	88/399 (22%)
		WD40 repeat	89..126	CDD:293791	11/38 (29%)
		WD40 repeat	132..170	CDD:293791	7/37 (19%)
		WD40 repeat	175..213	CDD:293791	8/41 (20%)
		WD40 repeat	220..299	CDD:293791	15/91 (16%)
		WD40 repeat	266..321	CDD:293791	12/73 (16%)
		WD40 repeat	326..365	CDD:293791	12/38 (32%)
		WD40 repeat	373..408	CDD:293791	12/34 (35%)
		WD40 repeat	414..438	CDD:293791	3/31 (10%)
SQT1	NP_012277.1	WD40	51..>392	CDD:225201	83/379 (22%)
		WD40 repeat	68..107	CDD:293791	11/38 (29%)
		WD40 repeat	113..162	CDD:293791	10/50 (20%)
		WD40 repeat	179..245	CDD:293791	12/65 (18%)
		WD40 repeat	257..307	CDD:293791	10/58 (17%)
		WD40 repeat	314..350	CDD:293791	12/41 (29%)
		WD40 repeat	355..391	CDD:293791	12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0296
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1562
Isobase	1	0.950	-	0	Normalized mean entropy	S3098
OMA	1	1.010	-	-		QHG53955
OrthoFinder	1	1.000	-	-		FOG0003404
OrthoInspector	1	1.000	-	-		oto99755
orthoMCL	1	0.900	-	-		OOG6_100610
Panther	1	1.100	-	-	LDO	PTHR19857
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1794
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740