DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and SWD3

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_009734.1	Gene:	SWD3 / 852472	SGDID:	S000000379	Length:	315	Species:	Saccharomyces cerevisiae

Alignment Length:	259	Identity:	63/259 - (24%)
Similarity:	101/259 - (38%)	Gaps:	52/259 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DRERIAAITDEATV-----------TFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDV 120
            |.:.||..:|:.:|           ||..|||||.:.:.:...|...|.|.|:...:|:|..|.:
Yeast    66 DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 130

  Fly   121 LYEITEHKDTVTETHF-SHDGVYLATGDLAGDLFVFKVSEKHDERPI-LTKIW--EYSMSDMSWL 181
            :..|:.|.:.|..... .:|...|::|...|.:.:|.....|..:.: ..|.|  |..:..:|.:
Yeast   131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195

  Fly   182 FWHRAAHILLAGSDSGEVFVFRIPSGECKILPGQSSRCESGEL------------SGDGKKLFTA 234
            .:...|..||..|..|.|.::....| |.:...|....|.|.|            .|....:.:.
Yeast   196 KFSENARYLLVKSLDGVVKIWDCIGG-CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259

  Fly   235 YVNGSVKLW--DLKSCQVLID---VNESHPM----GFGEITHAVVACERESPFYVCAEA-SGEC 288
            |.||.:..|  |.||...|:|   .:.|.|:    .||.|              :|:.| :|:|
Yeast   260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNI--------------MCSLALNGDC 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	59/247 (24%)
		WD40	<81..441	CDD:225201	58/234 (25%)
		WD40 repeat	89..126	CDD:293791	9/36 (25%)
		WD40 repeat	132..170	CDD:293791	6/39 (15%)
		WD40 repeat	175..213	CDD:293791	9/37 (24%)
		WD40 repeat	220..299	CDD:293791	22/91 (24%)
		WD40 repeat	266..321	CDD:293791	4/24 (17%)
		WD40 repeat	326..365	CDD:293791
		WD40 repeat	373..408	CDD:293791
		WD40 repeat	414..438	CDD:293791
SWD3	NP_009734.1	WD40	17..314	CDD:238121	63/259 (24%)
		WD40 repeat	17..53	CDD:293791
		WD40 repeat	59..94	CDD:293791	7/27 (26%)
		WD40 repeat	99..135	CDD:293791	8/35 (23%)
		WD40 repeat	142..178	CDD:293791	6/35 (17%)
		WD40 repeat	192..228	CDD:293791	9/36 (25%)
		WD40 repeat	236..284	CDD:293791	11/47 (23%)
		WD40 repeat	290..312	CDD:293791	7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010