DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and LST8-1

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_188442.1	Gene:	LST8-1 / 821339	AraportID:	AT3G18140	Length:	305	Species:	Arabidopsis thaliana

Alignment Length:	371	Identity:	74/371 - (19%)
Similarity:	135/371 - (36%)	Gaps:	127/371 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 TGSEDDRAFVWETSTGDVLYEITEHKDT-VTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPI 166
            |.|.|.....||..||. .|...::.|: |.....:.|..|||.. ....:.:|.|: .:..:|:
plant    10 TASYDHTIRFWEAETGR-CYRTIQYPDSHVNRLEITPDKHYLAAA-CNPHIRLFDVN-SNSPQPV 71

  Fly   167 LTKIWEYS-----------MSDMSWLFWHRAAHILLAGSDSGEVFVFRIPSGECK---------- 210
            :|    |.           ..|..|::         :||:.|.|.::.:.:..|:
plant    72 MT----YDSHTNNVMAVGFQCDAKWMY---------SGSEDGTVKIWDLRAPGCQKEYESVAAVN 123

  Fly   211 ---ILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLK----SCQVLIDVNESHPMGFGEITHA 268
               :.|.|:..     :|||        .||::::|||:    ||:::.:|:.:       :...
plant   124 TVVLHPNQTEL-----ISGD--------QNGNIRVWDLRANSCSCELVPEVDTA-------VRSL 168

  Fly   269 VVACERESPFYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFCTNNGPVSTIQSEHG--IECLAF 331
            .|..  :....|.|...|.|           :..:.:|.....|...|:..:|:.:|  ::|| .
plant   169 TVMW--DGTMVVAANNRGTC-----------YVWRLLRGKQTMTEFEPLHKLQAHNGHILKCL-L 219

  Fly   332 APSSADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVIRIKWLNDHTILAATSQGNLNAF 396
            :|::   |..|..|.|..:.||                                      |::.|
plant   220 SPAN---KYLATASSDKTVKIW--------------------------------------NVDGF 243

  Fly   397 DARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIFKVPA 442
            .     |:..||||...:::.|:......|:|.|.|.||:::.:||
plant   244 K-----LEKVLTGHQRWVWDCVFSVDGEFLVTASSDMTARLWSMPA 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	72/366 (20%)
		WD40	<81..441	CDD:225201	72/368 (20%)
		WD40 repeat	89..126	CDD:293791	8/22 (36%)
		WD40 repeat	132..170	CDD:293791	8/37 (22%)
		WD40 repeat	175..213	CDD:293791	7/50 (14%)
		WD40 repeat	220..299	CDD:293791	16/82 (20%)
		WD40 repeat	266..321	CDD:293791	8/54 (15%)
		WD40 repeat	326..365	CDD:293791	9/38 (24%)
		WD40 repeat	373..408	CDD:293791	3/34 (9%)
		WD40 repeat	414..438	CDD:293791	7/23 (30%)
LST8-1	NP_188442.1	WD40	7..281	CDD:238121	72/366 (20%)
		WD40 repeat	39..76	CDD:293791	9/42 (21%)
		WD40 repeat	81..117	CDD:293791	7/44 (16%)
		WD40 repeat	123..158	CDD:293791	12/47 (26%)
		WD40 repeat	165..208	CDD:293791	8/55 (15%)
		WD40 repeat	214..250	CDD:293791	12/82 (15%)
		WD40 repeat	256..280	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010