DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and sprb

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001122262.1	Gene:	sprb / 795445	ZFINID:	ZDB-GENE-070719-1	Length:	272	Species:	Danio rerio

Alignment Length:	328	Identity:	60/328 - (18%)
Similarity:	96/328 - (29%)	Gaps:	115/328 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ELRDRERIAAITDEATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHK 128
            |.||..|...:...|:..:.:..|...:|.|.|.           ...:..:.|.|.|.::   |
Zfish     8 ERRDLGRAVCVVTGASKGYGRTLALQISCLLKPR-----------SVLLLVSRTADQLNQL---K 58

  Fly   129 DTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAG 193
            ..:...|.:|..:.|                  |.|.:...:.|
Zfish    59 QDIVSLHAAHTDLQL------------------DVRCVQADLQE--------------------- 84

  Fly   194 SDSGEVFVFRIPSGECKILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESH 258
                       |.|..|.:  |.:|   ..||.|.:.|.  .:|.:..|.|:..|.|
Zfish    85 -----------PDGVQKTI--QETR---NTLSTDIEHLL--IINNAASLGDVSRCAV-------- 123

  Fly   259 PMGFGEITHAVVACERESPFYVCAEASGECSSGKGI-----------RYNTSFHNKTIRK----- 307
              .|.:      .||...  |:....||..|...||           |...:..:....|
Zfish   124 --SFTD------PCEVSR--YLALNVSGVLSLTAGILQAFPPAVGLRRTVVNISSLCALKPFPSW 178

  Fly   308 MLFCTNNGPVSTI-----QSEHGIECLAFAPS--SADLKLFA-C--GSLDGRISIWDYAKSALRT 362
            :|:||.......:     :.|..:..|::||.  ..|::|.| |  |:::.|.|...........
Zfish   179 VLYCTGKAARDMMFRVLAEEEPDLRVLSYAPGPLDTDMQLQARCFSGNVELRRSFSSMFSDGQLL 243

  Fly   363 ICE 365
            .||
Zfish   244 SCE 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	55/313 (18%)
		WD40	<81..441	CDD:225201	55/311 (18%)
		WD40 repeat	89..126	CDD:293791	6/36 (17%)
		WD40 repeat	132..170	CDD:293791	5/37 (14%)
		WD40 repeat	175..213	CDD:293791	3/37 (8%)
		WD40 repeat	220..299	CDD:293791	19/89 (21%)
		WD40 repeat	266..321	CDD:293791	13/75 (17%)
		WD40 repeat	326..365	CDD:293791	10/43 (23%)
		WD40 repeat	373..408	CDD:293791
		WD40 repeat	414..438	CDD:293791
sprb	NP_001122262.1	SPR-like_SDR_c	16..271	CDD:187625	56/320 (18%)
sprb	NP_001122262.1	adh_short	16..217	CDD:278532	48/289 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100610
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900