DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5114 and Wdr5b

DIOPT Version :9

Sequence 1:NP_001246760.1 Gene:CG5114 / 39624 FlyBaseID:FBgn0036460 Length:445 Species:Drosophila melanogaster
Sequence 2:NP_081389.1 Gene:Wdr5b / 69544 MGIID:1916794 Length:328 Species:Mus musculus


Alignment Length:349 Identity:66/349 - (18%)
Similarity:109/349 - (31%) Gaps:147/349 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 DRERIAAITDEATV------------TFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGD 119
            |..|:.:.:|:.|:            |.|.|:..||.|..:|..|..|:||.|:...:||..||.
Mouse    92 DSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGK 156

  Fly   120 VLYEITEHKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWH 184
            .|..::.|.|.::..:|:.:|..:.:|...|                |.:||:.:          
Mouse   157 CLKTLSAHSDPISAVNFNCNGSLIVSGSYDG----------------LCRIWDAA---------- 195

  Fly   185 RAAHILLAGSDSGEVFVFRIPSGEC-KILPGQSSRCES-GELSGDGKKLFTAYVNGSVKLWDLKS 247
                                 ||:| :.|..:.:...| .:.|.:||.:.||.::.::||||.  
Mouse   196 ---------------------SGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDNTLKLWDY-- 237

  Fly   248 CQVLIDVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFCT 312
                                                     |.|:.::..|...|:..       
Mouse   238 -----------------------------------------SRGRCLKTYTGHKNEKY------- 254

  Fly   313 NNGPVSTIQSEHGIECLAFAPSSADLKLFACGSLDGRISIW---------------DYAKSAL-- 360
                           ||..:.|....|....||.|..:.||               |...||.  
Mouse   255 ---------------CLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACH 304

  Fly   361 ---RTICENPVPNDAVIRIKWLND 381
               ..|....:.||..|:: |.:|
Mouse   305 PTKNIIASAALENDKTIKV-WSSD 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5114NP_001246760.1 WD40 79..439 CDD:295369 63/337 (19%)
WD40 <81..441 CDD:225201 62/323 (19%)
WD40 repeat 89..126 CDD:293791 14/36 (39%)
WD40 repeat 132..170 CDD:293791 5/37 (14%)
WD40 repeat 175..213 CDD:293791 3/38 (8%)
WD40 repeat 220..299 CDD:293791 12/79 (15%)
WD40 repeat 266..321 CDD:293791 4/54 (7%)
WD40 repeat 326..365 CDD:293791 13/58 (22%)
WD40 repeat 373..408 CDD:293791 3/9 (33%)
WD40 repeat 414..438 CDD:293791
Wdr5bNP_081389.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
WD40 31..325 CDD:238121 64/345 (19%)
WD40 <34..325 CDD:225201 64/345 (19%)
WD 1 37..76
WD40 repeat 42..79 CDD:293791
WD 2 79..120 5/27 (19%)
WD40 repeat 85..121 CDD:293791 5/28 (18%)
WD 3 122..162 15/39 (38%)
WD40 repeat 126..162 CDD:293791 14/35 (40%)
WD 4 163..202 12/85 (14%)
WD40 repeat 169..204 CDD:293791 10/81 (12%)
DDB1-binding motif 186..190 2/19 (11%)
WD 5 206..247 12/83 (14%)
WD40 repeat 211..247 CDD:293791 12/78 (15%)
WD 6 250..290 10/61 (16%)
WD40 repeat 255..292 CDD:293791 9/36 (25%)
WD 7 293..328 9/36 (25%)
WD40 repeat 298..324 CDD:293791 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53955
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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