DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and NWD2

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001138462.1	Gene:	NWD2 / 57495	HGNCID:	29229	Length:	1742	Species:	Homo sapiens

Alignment Length:	511	Identity:	86/511 - (16%)
Similarity:	170/511 - (33%)	Gaps:	170/511 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 IAAITDEATVTFKKHTAPVFACSLHP-------NYNWAVTGSEDDRAFVWETSTGDVLYEITEHK 128
            |..:.....||:.....|:.:..||.       |.:..:|..|:.....|:..|..:|.:||..:
Human   945 IVPLHSSMDVTYSPERLPLSSSHLHVTEILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQ 1009

  Fly   129 DTVTETHFSHDGVYLATGDLAGDLFVFK------VSE------KHDERPILTKIWEYSMS---DM 178
            ..:.....:.|..||........|.::.      :||      ||...  .|.|..:::|   .:
Human  1010 SVILGMKLTSDEKYLVVATTNNTLLIYDNVNSCLLSEVEIKGTKHGSS--ATYINGFTLSANHAL 1072

  Fly   179 SWL---------------------FWHRAAHI--------LLAGSDSGEVFVFRIPSGE--CKIL 212
            :||                     .|:....:        ...|.......:|.:.|||  |.:
Human  1073 AWLEASKDVTVIDLLYGWPLYQFHCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTV- 1136

  Fly   213 PGQSSRCESGELSGDGKK----LFTAY------VNGSVKLW---DLKSCQVLIDVNESHPMGFGE 264
                    :.|.||...|    |.||.      ..||:.:|   |:.|.|:..|.:
Human  1137 --------TSEFSGGFVKFLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFD--------- 1184

  Fly   265 ITHAVVACERESPFYVCAEASGECSS------------GKGI-----RYNTSFHNKTIRKMLFCT 312
                   |.||....|..|.|.:.|:            ..|:     ::....:.:.|..:|  :
Human  1185 -------CRREDSEVVSIELSEDQSAVLICKALSIELLDTGLWKVAEKFRAKHNERFISAVL--S 1240

  Fly   313 NNGP--VSTIQSEHGI--------ECLAFAP--SSADLKLFACG--------SLDGRISIWDY-A 356
            .||.  ::|:::...:        :|:|...  |.:.:||....        |..|.:||||. .
Human  1241 KNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDI 1305

  Fly   357 KSALRTICE--NPVPN-----------------------------DAVIRIKWLNDHTILAATSQ 390
            .:|:..|.:  .|:.:                             :||.:.:.:.:|.:|.:|..
Human  1306 ITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD 1370

  Fly   391 GNLNAFDARTGILKFTLTG------HYYHIYEFVYKPQENLLLTVSEDNTAKIFKV 440
            ..:.:.|..:..:..|.:|      :...|.:.:....:..::::.|:|.::::::
Human  1371 IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRL 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	85/500 (17%)
		WD40	<81..441	CDD:225201	84/501 (17%)
		WD40 repeat	89..126	CDD:293791	9/43 (21%)
		WD40 repeat	132..170	CDD:293791	9/49 (18%)
		WD40 repeat	175..213	CDD:293791	10/71 (14%)
		WD40 repeat	220..299	CDD:293791	22/108 (20%)
		WD40 repeat	266..321	CDD:293791	13/73 (18%)
		WD40 repeat	326..365	CDD:293791	13/57 (23%)
		WD40 repeat	373..408	CDD:293791	6/34 (18%)
		WD40 repeat	414..438	CDD:293791	3/23 (13%)
NWD2	NP_001138462.1	LRR 1	386..410
		AAA_16	394..539	CDD:289934
		LRR 2	677..698
		LRR 3	724..747
		LRR 4	883..906
		WD40	<922..1207	CDD:225201	55/288 (19%)
		LRR 5	925..953		1/7 (14%)
		WD 1	963..1004		8/40 (20%)
		WD40	978..1302	CDD:295369	64/352 (18%)
		WD 2	1007..1046		4/38 (11%)
		WD40 repeat	1013..1051	CDD:293791	6/37 (16%)
		WD40 repeat	1056..1095	CDD:293791	5/40 (13%)
		WD40	1100..1435	CDD:225201	58/354 (16%)
		WD40 repeat	1102..1138	CDD:293791	6/44 (14%)
		WD 3	1140..1179		11/38 (29%)
		WD40 repeat	1145..1184	CDD:293791	11/38 (29%)
		WD40 repeat	1192..1228	CDD:293791	5/35 (14%)
		WD 4	1229..1271		7/43 (16%)
		WD40 repeat	1235..1257	CDD:293791	5/23 (22%)
		WD40	1259..1507	CDD:295369	25/168 (15%)
		WD 5	1272..1311		10/38 (26%)
		WD40 repeat	1277..1313	CDD:293791	9/35 (26%)
		WD40	1303..>1580	CDD:225201	14/124 (11%)
		WD 6	1314..1353		1/38 (3%)
		WD40 repeat	1320..1354	CDD:293791	1/33 (3%)
		WD 7	1355..1394		6/38 (16%)
		WD40 repeat	1360..1396	CDD:293791	6/35 (17%)
		WD 8	1396..1434		3/31 (10%)
		WD40 repeat	1400..1440	CDD:293791	3/27 (11%)
		WD40 repeat	1444..1469	CDD:293791
		WD 9	1476..1516
		WD 10	1522..1564
		WD 11	1614..1653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19857
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030