DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and poc1a

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001016608.1	Gene:	poc1a / 549362	XenbaseID:	XB-GENE-5767105	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	77/365 - (21%)
Similarity:	126/365 - (34%)	Gaps:	87/365 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 FKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLATG 146
            ||.|...|.....:||.....:||.|....:|........|....|||.:....||..|..:|:.
Frog    14 FKGHRDTVTTVDFNPNTKQLASGSMDSCLMIWNMKPQMRAYRFVGHKDAILSVDFSPSGHLIASA 78

  Fly   147 DLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAGSDSGEVFVFRIPSGECKI 211
                            .|....::|..|:                    .||..||:..:|..:
Frog    79 ----------------SRDKTVRLWVPSV--------------------KGESTVFKAHTGTVR- 106

  Fly   212 LPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFGEITHA-VVACERE 275
                     |...||||:.|.||..:.::|:|.:...:.|..:|:          |. .|.|.:.
Frog   107 ---------SVSFSGDGQSLVTASDDKTIKVWTVHRQKFLFSLNQ----------HINWVRCAKF 152

  Fly   276 SP---FYVCAEASGECSSGKGIRYNTSFHNKTIRKML--FCTNNGPVSTIQSEHGIECLAFAPSS 335
            ||   ..|.|      |..|.|:    ..:||.|:.:  ||.:.|.|:.:.         |.||.
Frog   153 SPDGRLIVSA------SDDKTIK----LWDKTSRECIHSFCEHGGFVNFVD---------FHPSG 198

  Fly   336 ADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVIRIKW-LNDHTILAATSQGNLNAFDAR 399
            .   ..|..:.|..:.:||...:.|  |....|.:..|..:.: .:.:.::.|::...|...|..
Frog   199 T---CIAAAATDNTVKVWDIRMNKL--IQHYQVHSGVVNSLSFHPSGNYLITASNDSTLKVLDLL 258

  Fly   400 TGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIFK 439
            .|.|.:||.||...:....:..:.....:...|....::|
Frog   259 EGRLLYTLHGHQGPVTSVKFSREGEFFASGGSDEQVMVWK 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	76/363 (21%)
		WD40	<81..441	CDD:225201	77/365 (21%)
		WD40 repeat	89..126	CDD:293791	8/36 (22%)
		WD40 repeat	132..170	CDD:293791	5/37 (14%)
		WD40 repeat	175..213	CDD:293791	5/37 (14%)
		WD40 repeat	220..299	CDD:293791	22/82 (27%)
		WD40 repeat	266..321	CDD:293791	17/60 (28%)
		WD40 repeat	326..365	CDD:293791	9/38 (24%)
		WD40 repeat	373..408	CDD:293791	7/35 (20%)
		WD40 repeat	414..438	CDD:293791	1/23 (4%)
poc1a	NP_001016608.1	WD40	10..298	CDD:238121	76/363 (21%)
		WD 1	16..55		8/38 (21%)
		WD40 repeat	21..58	CDD:293791	8/36 (22%)
		WD 2	58..97		12/74 (16%)
		WD40 repeat	64..100	CDD:293791	11/71 (15%)
		WD 3	100..139		12/48 (25%)
		WD40 repeat	105..141	CDD:293791	11/45 (24%)
		WD 4	142..181		13/58 (22%)
		WD40 repeat	148..182	CDD:293791	11/43 (26%)
		WD 5	184..223		11/52 (21%)
		WD40 repeat	189..225	CDD:293791	10/49 (20%)
		WD 6	226..265		7/38 (18%)
		WD40 repeat	231..267	CDD:293791	7/35 (20%)
		WD 7	268..307		4/31 (13%)
		WD40 repeat	273..297	CDD:293791	1/23 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010