DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and aamp

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_998103.1	Gene:	aamp / 405874	ZFINID:	ZDB-GENE-040426-2370	Length:	420	Species:	Danio rerio

Alignment Length:	455	Identity:	147/455 - (32%)
Similarity:	231/455 - (50%)	Gaps:	67/455 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNTPPHRPDFDD-----GDDELQEIIELEEQPLDED--DDDLEEVTLEQLEARLAMAGGDDDEE- 59
            |:.|.  |:.:|     .|:|:.|:||||:.|...|  .|:||:|         .:|..|||:.
Zfish     7 DDNPD--PELEDTLQLHEDEEIIEVIELEDTPQSPDALADELEDV---------CVADDDDDDGW 60

  Fly    60 EDEEELRDRERIAAITDEATVTFKKHTAPVFACSLHPNYN-WAVTGSEDDRAFVWETSTGDVLYE 123
            :.|:||.:.|:     |::.:|..:||..||...|.|..| .|::|.||||||:|....|:||.|
Zfish    61 QTEDELMESEQ-----DDSELTLSRHTGSVFCVRLDPLTNSLAMSGGEDDRAFLWRVCDGEVLLE 120

  Fly   124 ITEHKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAH 188
            .|.|||:|....||.|....|:||::|.:.|:.| ||.:|      :|...:.|:.||.||..|.
Zfish   121 CTGHKDSVVCVGFSSDSALAASGDMSGVIRVWSV-EKREE------VWSAEVGDLEWLEWHPCAP 178

  Fly   189 ILLAGSDSGEVFVFRIPSGECKIL--PGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLK--SCQ 249
            :||||...|.|:::::|||.|:..  ||..:.|  |.:..|||:....|.:||::|||||  :..
Zfish   179 VLLAGVADGSVWMWKLPSGACRTFQSPGCQTTC--GRILPDGKRAIVGYEDGSLRLWDLKQGTAI 241

  Fly   250 VLIDVNESHPMGFGEITHAVVACERESPFYVCAEASGEC-----SSGKGIRYNTSFHNKTIRKML 309
            .:|...:.|.   |.:|  .|:..:|....:.....|:.     ||||.:   .||.::
Zfish   242 YVIKGQDGHR---GALT--CVSSNQEGALLLSGSVDGQAKLISSSSGKVL---CSFSSQ------ 292

  Fly   310 FCTNNGPVSTIQSEHGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVI 374
              |:.|..|. |..:.:|.:.|...   |.|.|...|||.::|:|.....||..|::.|   .|:
Zfish   293 --TSEGSGSA-QDSNSVESVGFCNV---LPLAAVAYLDGTLAIYDLNTHTLRHQCKHEV---GVV 348

  Fly   375 RIKWLNDHTILAATS-QGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIF 438
            :::|..:..::...| .|.|:.:|||:|:|.....||...|.:||...:.::.:|...|:.||:|
Zfish   349 QLQWEAESAVVCTCSLSGVLSLWDARSGVLVSEFHGHSAEILDFVLNREASVAVTAGGDHKAKVF 413

Fly 439 438
Zfish 414 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	121/371 (33%)
		WD40	<81..441	CDD:225201	121/369 (33%)
		WD40 repeat	89..126	CDD:293791	18/37 (49%)
		WD40 repeat	132..170	CDD:293791	12/37 (32%)
		WD40 repeat	175..213	CDD:293791	16/39 (41%)
		WD40 repeat	220..299	CDD:293791	23/85 (27%)
		WD40 repeat	266..321	CDD:293791	13/59 (22%)
		WD40 repeat	326..365	CDD:293791	12/38 (32%)
		WD40 repeat	373..408	CDD:293791	10/35 (29%)
		WD40 repeat	414..438	CDD:293791	7/23 (30%)
aamp	NP_998103.1	WD40	77..372	CDD:238121	106/326 (33%)
		WD40	<79..416	CDD:225201	120/367 (33%)
		WD40 repeat	85..123	CDD:293791	18/37 (49%)
		WD40 repeat	160..203	CDD:293791	17/42 (40%)
		WD40 repeat	210..245	CDD:293791	13/36 (36%)
		WD40 repeat	254..290	CDD:293791	9/40 (23%)
		WD40 repeat	306..338	CDD:293791	10/34 (29%)
		WD40 repeat	347..371	CDD:293791	5/23 (22%)
		WD40 repeat	389..415	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592955
Domainoid	1	1.000	43	1.000	Domainoid score	I12405
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H846
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3814
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1025450at2759
OrthoFinder	1	1.000	-	-		FOG0003404
OrthoInspector	1	1.000	-	-		oto40743
orthoMCL	1	0.900	-	-		OOG6_100610
Panther	1	1.100	-	-	LDO	PTHR19857
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1794
SonicParanoid	1	1.000	-	-		X3860
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900