DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and Tbl1x

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001100434.1	Gene:	Tbl1x / 302711	RGDID:	1563868	Length:	527	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	82/400 - (20%)
Similarity:	135/400 - (33%)	Gaps:	129/400 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVW---ETSTGD----VL--------YEITE 126
            :||| .:.|.:.||.|:.:|..:...:||.|..|.:|   |.|.|.    ||        :::..
  Rat   174 KATV-LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 237

  Fly   127 HKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILL 191
            :|| ||...::.||..||||...|                ..:||....:..|.|
  Rat   238 NKD-VTSLDWNSDGTLLATGSYDG----------------FARIWTEDGNLASTL---------- 275

  Fly   192 AGSDSGEVFVFRIPSGECKILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQV------ 250
             |...|.:|..:                    .:..|..:.:|.|:.:..:||..:.:.
  Rat   276 -GQHKGPIFALK--------------------WNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPF 319

  Fly   251 ----LIDVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFC 311
                .:||:..:...|       .:|..:...:||                          .|.|
  Rat   320 HSAPALDVDWQNNTTF-------ASCSTDMCIHVC--------------------------RLGC 351

  Fly   312 TNNGPVSTIQSE-HGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICENPVP--NDAV 373
              :.||.|.|.. :.:..:.:.||.   .|.|..|.|..:.||...:.|    |.:.:.  :..:
  Rat   352 --DRPVKTFQGHTNEVNAIKWDPSG---MLLASCSDDMTLKIWSMKQDA----CVHDLQAHSKEI 407

  Fly   374 IRIKWL---------NDHTILAATS-QGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLT 428
            ..|||.         |.:.:||:.| ...:..:|...|:...|||.|...:|...:.|....|.:
  Rat   408 YTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLAS 472

  Fly   429 VSEDNTAKIF 438
            .|.|....|:
  Rat   473 GSFDKCVHIW 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	81/397 (20%)
		WD40	<81..441	CDD:225201	79/395 (20%)
		WD40 repeat	89..126	CDD:293791	14/51 (27%)
		WD40 repeat	132..170	CDD:293791	8/37 (22%)
		WD40 repeat	175..213	CDD:293791	5/37 (14%)
		WD40 repeat	220..299	CDD:293791	11/88 (13%)
		WD40 repeat	266..321	CDD:293791	8/54 (15%)
		WD40 repeat	326..365	CDD:293791	9/38 (24%)
		WD40 repeat	373..408	CDD:293791	10/44 (23%)
		WD40 repeat	414..438	CDD:293791	5/23 (22%)
Tbl1x	NP_001100434.1	LisH	7..31	CDD:369916
		WD40	177..483	CDD:238121	80/396 (20%)
		WD40 repeat	185..232	CDD:293791	14/46 (30%)
		WD40 repeat	242..277	CDD:293791	12/61 (20%)
		WD40 repeat	282..318	CDD:293791	6/55 (11%)
		WD40 repeat	325..359	CDD:293791	11/68 (16%)
		WD40 repeat	365..401	CDD:293791	10/42 (24%)
		WD40 repeat	407..452	CDD:293791	10/44 (23%)
		WD40 repeat	458..482	CDD:293791	5/23 (22%)
		WD40 repeat	499..525	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010