DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5114 and Katnb1

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_017456687.1	Gene:	Katnb1 / 291852	RGDID:	1311256	Length:	659	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	86/434 - (19%)
Similarity:	133/434 - (30%)	Gaps:	178/434 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ELQEIIELEEQPLDEDDDDLEEVTLEQLEARLAMAGGDDDEEEDEEELRDRERIAAIT-DEATVT 81
            :||||:        ....::..:.|.:...||...||||          .|..:.:|. ....::
  Rat    12 KLQEIV--------AHASNVSSLVLGKASGRLLATGGDD----------CRVNLWSINKPNCIMS 58

  Fly    82 FKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLATG 146
            ...||:||.:..|:......|.||:.....||:.....:|..:..||..:....|...|.::|:|
  Rat    59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123

  Fly   147 DLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAGSDSGEVFVFRIPSGECKI 211
            ....::                |:|:...                    .|.||.:|..|
  Rat   124 SQDTNI----------------KLWDIRR--------------------KGCVFRYRGHS----- 147

  Fly   212 LPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFGEITHAVVACERES 276
               |:.||.  ..|.|||.|.:|..:.:||||||
  Rat   148 ---QAVRCL--RFSPDGKWLASAADDHTVKLWDL------------------------------- 176

  Fly   277 PFYVCAEASGECSSGKGIRYNTSFHNKTIRKML--FCTNNGPVSTIQSEHGIECLAFAPSSADLK 339
                                       |..||:  |..:.|||:.::         |.|:.   .
  Rat   177 ---------------------------TAGKMMSEFPGHTGPVNVVE---------FHPNE---Y 202

  Fly   340 LFACGSLDGRISIWDYAK-----------SALRTICENP------------------VPNDA--V 373
            |.|.||.|..|..||..|           ..:|::..||                  .|...  |
  Rat   203 LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDV 267

  Fly   374 IRIKW--------LNDHTILAATSQGNLNAFDARTGILKFTLTG 409
            :.:.|        .||..|..|.||.|::::  ...:.:.|.||
  Rat   268 VLVNWGKVADLAICNDQLIGVAFSQSNVSSY--VVDLTRVTRTG 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	73/372 (20%)
		WD40	<81..441	CDD:225201	73/370 (20%)
		WD40 repeat	89..126	CDD:293791	8/36 (22%)
		WD40 repeat	132..170	CDD:293791	4/37 (11%)
		WD40 repeat	175..213	CDD:293791	5/37 (14%)
		WD40 repeat	220..299	CDD:293791	12/78 (15%)
		WD40 repeat	266..321	CDD:293791	7/56 (13%)
		WD40 repeat	326..365	CDD:293791	12/49 (24%)
		WD40 repeat	373..408	CDD:293791	10/42 (24%)
		WD40 repeat	414..438	CDD:293791
Katnb1	XP_017456687.1	WD40	7..257	CDD:238121	73/378 (19%)
		WD40 repeat	67..103	CDD:293791	7/35 (20%)
		WD40 repeat	108..144	CDD:293791	9/71 (13%)
		WD40 repeat	151..186	CDD:293791	17/94 (18%)
		WD40 repeat	192..228	CDD:293791	12/47 (26%)
		WD40 repeat	234..261	CDD:293791	3/26 (12%)
		PRK14951	<386..>494	CDD:237865
		Katanin_con80	497..652	CDD:404758
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910