DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and hif2

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_587735.1	Gene:	hif2 / 2538701	PomBaseID:	SPCC1235.09	Length:	564	Species:	Schizosaccharomyces pombe

Alignment Length:	399	Identity:	83/399 - (20%)
Similarity:	140/399 - (35%)	Gaps:	149/399 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EDEEELRDRERIAAITDEATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEI 124
            :|:.|.||.:  ..:.||:.|. |....|:...:..|     ||                   ||
pombe   146 KDKIEKRDID--ITMADESNVE-KDPARPIAVYNSSP-----VT-------------------EI 183

  Fly   125 TEHKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKH-----DERPILTK---IWEYS--MSDMS 179
            ||.|..          .:....|:..|.|.. :..||     |.||:|.:   ::|:|  |::.:
pombe   184 TEIKQV----------TFTGGEDIKSDFFKV-IPTKHPVTCADWRPLLQENYHVYEFSIGMTNAT 237

  Fly   180 WLFWHRAAHILLAGSDSGEVFVFRIPSGECKILPGQSSRCESGELSG-----DGKKLFTAYVNGS 239
                      |.:.|...|...|:..:..|.    ||| .::.:::|     .|..|..|:.:|.
pombe   238 ----------LASVSICEEQNDFKAKTDYCL----QSS-FDNQDITGVAWNNSGSFLAYAFFSGV 287

  Fly   240 VKLWDLKSCQVLIDVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFHNKT 304
            ::::|....|:|                                               ||||
pombe   288 IEIYDSHGSQIL-----------------------------------------------SFHN-- 303

  Fly   305 IRKMLFCTNNGPVSTIQSEHGIECLAFAPSSADLKLFACGSLDGRISIWDYAKS---ALRTICEN 366
                    |.|||           |:...|..|..| |.||.||.|:::|..|.   ::.|:.
pombe   304 --------NKGPV-----------LSLKWSGTDTYL-AAGSADGTITLFDQLKQTQYSIDTLA-- 346

  Fly   367 PVPNDAVIRIKWLNDHTILAATSQGNLNAF--DARTGILKFTLTGHYYHIYEFVYKPQENLLLTV 429
                .:|:.|:|::....:.:..:|:|..:  |.:..:...: ..|...|....|..:.:||||.
pombe   347 ----SSVLDIEWISFDEFVTSDVEGSLRVYKVDGKAPVSTVS-HAHDNSIVALRYNLRISLLLTA 406

  Fly   430 SEDNTAKIF 438
            |.|.|.|::
pombe   407 SSDTTVKLW 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	77/380 (20%)
		WD40	<81..441	CDD:225201	76/378 (20%)
		WD40 repeat	89..126	CDD:293791	5/36 (14%)
		WD40 repeat	132..170	CDD:293791	9/45 (20%)
		WD40 repeat	175..213	CDD:293791	6/37 (16%)
		WD40 repeat	220..299	CDD:293791	8/83 (10%)
		WD40 repeat	266..321	CDD:293791	8/54 (15%)
		WD40 repeat	326..365	CDD:293791	13/41 (32%)
		WD40 repeat	373..408	CDD:293791	6/36 (17%)
		WD40 repeat	414..438	CDD:293791	10/23 (43%)
hif2	NP_587735.1	LisH	4..30	CDD:285685
		WD40	<263..524	CDD:225201	46/229 (20%)
		WD40	267..523	CDD:295369	46/225 (20%)
		WD40 repeat	267..301	CDD:293791	8/80 (10%)
		WD40 repeat	309..347	CDD:293791	13/44 (30%)
		WD40 repeat	349..384	CDD:293791	6/34 (18%)
		WD40 repeat	392..430	CDD:293791	9/24 (38%)
		WD40 repeat	435..472	CDD:293791
		WD40 repeat	478..515	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010