DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and wdr-5.2

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_510394.1	Gene:	wdr-5.2 / 181540	WormBaseID:	WBGene00010572	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	316	Identity:	67/316 - (21%)
Similarity:	108/316 - (34%)	Gaps:	112/316 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DRERIAAITDEATV------------TFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGD 119
            |.:.|.:.:|:..|            |.|.||..||.|..:|:.....:||.|:...:|....|:
Worm   159 DSKLIVSCSDDKLVKVFDVSSGRCVKTLKGHTNYVFCCCFNPSGTLIASGSFDETIRIWCARNGN 223

  Fly   120 VLYEITEHKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWH 184
            .::.|..|:|.|:...|:.||.|||:|...|                :.:||:.:
Worm   224 TIFSIPGHEDPVSSVCFNRDGAYLASGSYDG----------------IVRIWDST---------- 262

  Fly   185 RAAHILLAGSDSGEVFVFRIPSGEC--KILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKS 247
                                 :|.|  .::..:.......:.|.:||.:..:.:|.::||||.:.
Worm   263 ---------------------TGTCVKTLIDEEHPPITHVKFSPNGKYILASNLNNTLKLWDYQK 306

  Fly   248 CQVLIDVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFH-----NKTIRK 307
            .:||.:.. .|                |:..| |..|:...:.||.|...:..|     |...|:
Worm   307 LRVLKEYT-GH----------------ENSKY-CVAANFSVTGGKWIVSGSEDHKVYIWNLQTRE 353

  Fly   308 ML----------FCTNNGPVSTIQSEHGIECLAFAPSSADLKLFACGSLDGRISIW 353
            :|          .||:..|...|     |...|..|             |.||.||
Worm   354 ILQTLDGHNTAVMCTDCHPGQNI-----IASAALEP-------------DMRIKIW 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	64/304 (21%)
		WD40	<81..441	CDD:225201	63/290 (22%)
		WD40 repeat	89..126	CDD:293791	10/36 (28%)
		WD40 repeat	132..170	CDD:293791	8/37 (22%)
		WD40 repeat	175..213	CDD:293791	2/39 (5%)
		WD40 repeat	220..299	CDD:293791	18/78 (23%)
		WD40 repeat	266..321	CDD:293791	14/69 (20%)
		WD40 repeat	326..365	CDD:293791	8/28 (29%)
		WD40 repeat	373..408	CDD:293791
		WD40 repeat	414..438	CDD:293791
wdr-5.2	NP_510394.1	WWbp	<1..87	CDD:304964
		WD40	<104..395	CDD:225201	67/316 (21%)
		WD40	106..392	CDD:238121	67/316 (21%)
		WD40 repeat	110..146	CDD:293791
		WD40 repeat	152..188	CDD:293791	5/28 (18%)
		WD40 repeat	193..229	CDD:293791	9/35 (26%)
		WD40 repeat	236..271	CDD:293791	12/81 (15%)
		WD40 repeat	278..314	CDD:293791	10/35 (29%)
		WD40 repeat	322..359	CDD:293791	9/36 (25%)
		WD40 repeat	365..391	CDD:293791	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010