DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and ZK430.7

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001370319.1	Gene:	ZK430.7 / 173778	WormBaseID:	WBGene00022742	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	72/379 - (18%)
Similarity:	121/379 - (31%)	Gaps:	103/379 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TDEATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHD 139
            ||:.....:....|.........|..|:..::.:|.|.               |..|.......|
Worm    18 TDKRNKIVRNFNTPADPFRSQVEYTRALNATKLERVFA---------------KPFVASLDGHVD 67

  Fly   140 GVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAGSDSGEVFVFRI 204
            ||              :|..||..||             |.:|         :|:..|:|.::.:
Worm    68 GV--------------QVLAKHPNRP-------------STVF---------SGARDGQVKIWNL 96

  Fly   205 PSGECKILPGQSSRCESGELSGD---GKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFGEIT 266
            .|.||:... .:.|....::|.|   |:...|...:..:|.|.::..|    ...:|.:....|.
Worm    97 ASRECQATL-DAHRGLVNDISIDNNNGENFVTVGQDNQLKYWKIEGQQ----KTPAHSIAMDGIV 156

  Fly   267 HAVVACERESPFYVCAEASGECSSGKGIR------YNTSFHNKTIRKMLFCTNNGPVSTIQSEHG 325
            :.|......|.|..|.|   :.|..|..|      ||..  ..||..   |..| ||     |..
Worm   157 YGVSHLSFSSDFVTCGE---DISVWKPYRETPLRSYNLG--TDTIHT---CRAN-PV-----EEN 207

  Fly   326 IECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVIRIKW--LNDHTILAAT 388
            :    ...:.:|..::.   ||.|..:      .|:.:.....||    :|.|  :..:....|:
Worm   208 V----IVGARSDRSIYV---LDTRQDV------PLKKVTMKMRPN----KISWNPMEAYNFTVAS 255

  Fly   389 SQGNLNAFDARTGILKFTLTGHY---YHIYEFVYKPQENLLLTVSEDNTAKIFK 439
            ...:|..||.|  .::..:..|.   ..:.:..|.|.....:....|.:.::||
Worm   256 EDYSLYTFDMR--YMEHPVQSHQGFTSAVLDVDYSPTGQEFVAAGYDRSIRLFK 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	68/373 (18%)
		WD40	<81..441	CDD:225201	70/373 (19%)
		WD40 repeat	89..126	CDD:293791	4/36 (11%)
		WD40 repeat	132..170	CDD:293791	8/37 (22%)
		WD40 repeat	175..213	CDD:293791	8/37 (22%)
		WD40 repeat	220..299	CDD:293791	19/87 (22%)
		WD40 repeat	266..321	CDD:293791	16/60 (27%)
		WD40 repeat	326..365	CDD:293791	5/38 (13%)
		WD40 repeat	373..408	CDD:293791	7/36 (19%)
		WD40 repeat	414..438	CDD:293791	3/23 (13%)
ZK430.7	NP_001370319.1	WD40	59..350	CDD:421866	64/323 (20%)
		WD40 repeat	160..191	CDD:293791	8/33 (24%)
		WD40 repeat	196..233	CDD:293791	11/58 (19%)
		WD40 repeat	239..276	CDD:293791	8/42 (19%)
		WD40 repeat	282..319	CDD:293791	5/26 (19%)
		WD40 repeat	325..361	CDD:293791
		Sof1	351..>420	CDD:398022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000