DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and AAMP

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_024308480.1	Gene:	AAMP / 14	HGNCID:	18	Length:	459	Species:	Homo sapiens

Alignment Length:	392	Identity:	122/392 - (31%)
Similarity:	191/392 - (48%)	Gaps:	71/392 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NTPPHRPDFDDGDDELQEIIELEEQPLDEDD--DDLEEVTLEQLEARLAMAGGDDDEEEDEEE-- 64
            :|||.......||:|:.|::||:..|.|.||  .::|:|..|           :::|||..||
Human    12 DTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFE-----------EEEEEEGNEEGW 65

  Fly    65 -LRDRERIAAI---TDEATVTFKKHTAPVFACSLHPNYN-WAVTGSEDDRAFVWETSTGDVLYEI 124
             |..:|.:...   .|::.|||..|:|.||..||.|..| .||||.|||:||||..|.|::|:|.
Human    66 VLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFEC 130

  Fly   125 TEHKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHI 189
            ..|||:||...||||...:||||::|.|.|::|..|.:       :|.:...|:.|:.||..|.:
Human   131 AGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEE-------VWSFEAGDLEWMEWHPRAPV 188

  Fly   190 LLAGSDSGEVFVFRIPSGECKILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVL--I 252
            ||||:..|..:::::|:|:||...|.:.....|.:..|||:....|.:|::::||||....:  :
Human   189 LLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVL 253

  Fly   253 DVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFCTNNGPV 317
            ...|.|.   |.:|  .||..::....:  ..|.:|.:                |::..|....|
Human   254 KGTEGHQ---GPLT--CVAANQDGSLIL--TGSVDCQA----------------KLVSATTGKVV 295

  Fly   318 STIQSE----------------HGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICEN 366
            ...:.|                :.:|.|.|.   :.:.|.|.|.|||.::|:|.|...||..|::
Human   296 GVFRPETVASQPSLGEGEESESNSVESLGFC---SVMPLAAVGYLDGTLAIYDLATQTLRHQCQH 357

  Fly   367 PV 368
            .|
Human   358 QV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	98/309 (32%)
		WD40	<81..441	CDD:225201	97/307 (32%)
		WD40 repeat	89..126	CDD:293791	21/37 (57%)
		WD40 repeat	132..170	CDD:293791	14/37 (38%)
		WD40 repeat	175..213	CDD:293791	14/37 (38%)
		WD40 repeat	220..299	CDD:293791	18/80 (23%)
		WD40 repeat	266..321	CDD:293791	8/54 (15%)
		WD40 repeat	326..365	CDD:293791	14/38 (37%)
		WD40 repeat	373..408	CDD:293791
		WD40 repeat	414..438	CDD:293791
AAMP	XP_024308480.1	WD40	86..361	CDD:238121	97/307 (32%)
		WD40 repeat	94..132	CDD:293791	21/37 (57%)
		WD40 repeat	169..212	CDD:293791	15/42 (36%)
		WD40 repeat	219..254	CDD:293791	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0296
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H846
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3712
Isobase	1	0.950	-	0	Normalized mean entropy	S3098
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1025450at2759
OrthoFinder	1	1.000	-	-		FOG0003404
OrthoInspector	1	1.000	-	-		oto90294
orthoMCL	1	0.900	-	-		OOG6_100610
Panther	1	1.100	-	-	LDO	PTHR19857
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1794
SonicParanoid	1	1.000	-	-		X3860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750